Achard, Daniel et al. published their patent in 1992 |CAS: 81616-80-0

The Article related to thiopyranopyrrole perhydro preparation antagonist substance p, perhydrothiopyranopyrrole preparation antagonist substance p, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Product Details of 81616-80-0

On November 19, 1992, Achard, Daniel; Moutonnier, Claude; Peyronel, Jean Francois; Tabart, Michel; Truchon, Alain published a patent.Product Details of 81616-80-0 The title of the patent was Preparation of thiopyranopyrrole derivatives as substance P antagonists. And the patent contained the following:

The preparation of perhydrothiopyranopyrroles and oxide derivatives I [Z = O, NH; R1 = (un)substituted Ph, cyclohexadienyl, naphthyl, heterocyclyl; R2 = H, halo, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, acyloxy, carboxy, alkoxycarbonyl, benzyloxycarbonyl, amino, acylamino; n = 0-2], stereoisomers and their mixtures, and salts is claimed. The compounds are particularly interesting as substance P antagonists. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Product Details of 81616-80-0

The Article related to thiopyranopyrrole perhydro preparation antagonist substance p, perhydrothiopyranopyrrole preparation antagonist substance p, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Product Details of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem