On March 12, 2012, Zang, Qin; Javed, Salim; Porubsky, Patrick; Ullah, Farman; Neuenswander, Benjamin; Lushington, Gerald H.; Basha, Fatima Z.; Organ, Michael G.; Hanson, Paul R. published an article.Quality Control of (2-Bromo-5-methoxyphenyl)methanamine The title of the article was Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy. And the article contained the following:
The synthesis of a unique isoindoline- and tetrahydroisoquinoline (THIQ)-containing tricyclic sultam library, utilizing a Heck-aza-Michael strategy is reported. Both isoindoline and THIQ rings are installed through a Heck reaction on a vinylsulfonamide, followed by one-pot deprotection and intramol. aza-Michael reaction. Subsequent cyclization with either paraformaldehyde condensation or 1,1′-carbonyldiimidazole coupling generates a variety of tricyclic sultams, e.g., I. Overall, a 160-member library of these sultams, together with their isoindolines/THIQ and secondary sulfonamides precursors, were constructed using this strategy. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Quality Control of (2-Bromo-5-methoxyphenyl)methanamine
The Article related to bromoarylalkylamine vinylsulfonamide hexk reaction, aminoalkylarylvinylsulfonamide preparation aza michael reaction, isoindolylmethylsulfonamide preparation cyclization, tricyclic sultam preparation and other aspects.Quality Control of (2-Bromo-5-methoxyphenyl)methanamine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem