On March 31, 2022, Wang, Mingqi; Zhou, Jingjing; Zhang, Guoxian; Liu, Qing; Zhang, Qiuyu published an article.Computed Properties of 929-37-3 The title of the article was Pyrrolidinyl ligand motif-assisted bovine serum albumin molecularly imprinted polymers with high specificity. And the article contained the following:
Ideal binding ligands for anchoring proteins are essential for the design and assembly of desirable molecularly imprinted polymers (MIPs). In this study, bovine serum albumin-MIPs (BSA-MIPs) were successfully prepared by orchestrating the involvement of orientation-controllable binding ligands via sequential thiol-ene click and thiol-ene-amine conjugation. We showed that the optimal thiol-ene-amine conjugates and binding ligands were decisive in determining the rebinding capacity and selectivity. The pyrrolidinyl MIPs exhibited the best adsorption capacity of 352 卤 22 mg/g and a superior imprinting factor of 4.72 among MIPs with various binding ligands. These favorable results were further studied by computational simulation and isothermal titration calorimetry (ITC). Mol. docking revealed the preferential binding free energy and H-bonds between BSA residues and the thiol-ene-amine conjugates. Meanwhile, the pyrrolidinyl ligand motif enabled entropy-favorable affinity to be achieved via hydrophobic effects with the BSA template by ITC thermodn. Because of these favorable bindings, the MIPs exhibited excellent adsorption specificity to BSA over competing proteins. The proof-of-concept of MIPs with orientation-controllable conjugates and proven binding ligands for target proteins demonstrates that this material is promising for use with a real biol. sample. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Computed Properties of 929-37-3
The Article related to pyrrolidinyl ligand bovine serum albumin molecularly imprinted polymer, adsorption capacity, hydrophobic effect, molecularly imprinted polymers (mips), pyrrolidinyl group, thiol-ene-amine conjugation and other aspects.Computed Properties of 929-37-3
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