On August 1, 2022, Sukowski, Verena; van Borselen, Manuela; Mathew, Simon; Fernandez-Ibanez, M. Angeles published an article.Application In Synthesis of 2-Methylanisole The title of the article was S,O-Ligand Promoted meta-C-H Arylation of Anisole Derivatives via Palladium/Norbornene Catalysis. And the article contained the following:
Here, a new catalytic system based on palladium/norbornene and an S,O-ligand for the meta-C-H arylation of aryl ethers that significantly outperforms previously reported systems has been developed. The unique ability of this system to employ alkoxyarene substrates bearing electron donating and withdrawing substituents is demonstrated. Addnl., ortho-substituted aryl ethers are well tolerated, overcoming the “ortho constraint”, which is the necessity to have a meta-substituent on the alkoxyarene to achieve high reaction efficiency, by enlisting novel norbornene mediators. Remarkably, for the first time the monoarylation of alkoxyarenes is achieved efficiently enabling the subsequent introduction of a second, different aryl coupling partner to rapidly furnish unsym. terphenyls. Further insight into the reaction mechanism was achieved by isolation and characterization of some Pd-complexes-before and after meta C-H activation-prior to evaluation of their resp. catalytic activities. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Application In Synthesis of 2-Methylanisole
The Article related to biphenyl terphenyl alkoxy preparation, aryl ether regioselective arylation aryl halide palladium norbornene catalyst, arylation, c鈭抙 activation, ligand design, palladium, reaction mechanisms and other aspects.Application In Synthesis of 2-Methylanisole
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem