Otani, Takashi; Jiang, Xue; Cho, Kinryo; Araki, Rino; Kutsumura, Noriki; Saito, Takao published an article in 2015, the title of the article was Lewis Acid-Catalyzed or Base-Promoted Regioselective Cycloisomerization of N-Imidoyl-o-alkynylanilines for Synthesis of N-Imidoyl-(1H)-indoles and 4-Alkylidene-3,4-dihydroquinazolines.SDS of cas: 157869-15-3 And the article contains the following content:
The product selectivity control for the synthesis of imidoylindoles I (R1 = 4-Tol, Ph, t-Bu, n-Pr, etc; R2 = Ph, n-Pr, i-Pr; R3 = Ph, Et) and 4-alkylidenedihydroquinazolines II (R4 = 4-CH3OC6H4, 4-F3CC6H4, cyclohexyl, etc; R5 = Ph, n-Pr, i-Pr, t-Bu) from N-imidoyl-o-alkynylanilines via silver triflate-catalyzed cycloisomerization or tetrabutylammonium fluoride-promoted cyclization were described. The product selectivity depends mainly on the catalyst/promoter used, and on the substituents on the alkyne and amidine functions of the substrates. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).SDS of cas: 157869-15-3
The Article related to indole imidoyl quinazoline dihydro alkylidene preparation diastereoselective regioselective, aniline alkynyl imidoyl cycloisomerization silver triflate catalyst cyclization tbaf and other aspects.SDS of cas: 157869-15-3
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