On February 1, 2021, Murugesan, Kathiravan; Donabauer, Karsten; Koenig, Burkhard published an article.Related Products of 578-58-5 The title of the article was Visible-Light-Promoted Metal-Free Synthesis of (Hetero)Aromatic Nitriles from C(sp3)-H Bonds. And the article contained the following:
The metal-free activation of C(sp3)-H bonds to value-added products is of paramount importance in organic synthesis. We report the use of the com. available organic dye 2,4,6-triphenylpyrylium tetrafluoroborate (TPP) for the conversion of methylarenes to the corresponding aryl nitriles via a photocatalytic process. Applying this methodol., a variety of cyanobenzenes have been synthesized in good to excellent yield under metal- and cyanide-free conditions. We demonstrate the scope of the method with over 50 examples including late-stage functionalization of drug mols. (celecoxib) and complex structures such as L-menthol, amino acids, and cholesterol derivatives Furthermore, the presented synthetic protocol is applicable for gram-scale reactions. In addition to methylarenes, selected examples for the cyanation of aldehydes, alcs. and oximes are demonstrated as well. Detailed mechanistic investigations have been carried out using time-resolved luminescence quenching studies, control experiments, and NMR spectroscopy as well as kinetic studies, all supporting the proposed catalytic cycle. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Related Products of 578-58-5
The Article related to photocatalytic cyanation methylarene aldehyde alc oxime, visible light promoted synthesis heteroaromatic aromatic nitrile, c鈭抙 functionalization, ammoxidation, methylarenes, nitriles, photoredox catalysis and other aspects.Related Products of 578-58-5
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Ether | (C2H5)2O – PubChem