On May 6, 2016, Li, Jing; Shen, Jiefeng; Xia, Chao; Wang, Yanzhao; Liu, Delong; Zhang, Wanbin published an article.Recommanded Product: 81616-80-0 The title of the article was Asymmetric Hydrogenation of 伪-Substituted Acrylic Acids Catalyzed by a Ruthenocenyl Phosphino-oxazoline-Ruthenium Complex. And the article contained the following:
Asym. hydrogenation of various 伪-substituted acrylic acids was carried out using RuPHOX-Ru as a chiral catalyst under 5 bar H2, affording the corresponding chiral 伪-substituted propanoic acids in up to 99% yield and 99.9% ee. The reaction could be performed on a gram-scale with a relatively low catalyst loading (up to 5000 S/C), and the resulting product (97%, 99.3% ee) can be used as a key intermediate to construct bioactive chiral mols. The asym. protocol was successfully applied to an asym. synthesis of dihydroartemisinic acid, a key intermediate required for the industrial synthesis of the antimalarial drug artemisinin. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Recommanded Product: 81616-80-0
The Article related to chiral propanoic acid preparation, asym hydrogenation acrylic acid ruthenocenyl phosphino oxazoline complex catalyst, dihydroartemisinic acid synthon synthesis antimalarial drug artemisinin and other aspects.Recommanded Product: 81616-80-0
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