Dhandabani, Ganesh Kumar; Mutra, Mohana Reddy; Wang, Jeh-Jeng published an article in 2018, the title of the article was Palladium-Catalyzed Regioselective Synthesis of 1-Benzoazepine Carbonitriles from o-Alkynylanilines via 7-endo-dig Annulation and Cyanation.Application of 157869-15-3 And the article contains the following content:
A three-component, one-pot cascade reaction involving an imination/annulation/cyanation sequence was reported for the synthesis of 1-benzoazepine carbonitrile derivatives I [R = 2-thienyl, Ph, 3-ClC6H4, etc.; R1 = H, 8-Me, 7-CF3, etc.; R2 = H, 2-Me, 3-Me, 3-t-Bu] using readily available o-alkynylanilines, cyclic ketones and trimethylsilyl cyanide. This regio- and stereoselective reaction was achieved by combining palladium(II) trifluoroacetate and copper(II) acetate in DMSO. The important features of this method included a broad substrate scope, the use of trimethylsilyl cyanide as a cyanating agent, the formation of two C-C bonds and one C-N bond, mild reaction conditions and good product yields. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application of 157869-15-3
The Article related to benzoazepine carbonitrile preparation regioselective diastereoselective crystal structure mol, alkynylaniline cyaclohexane tmscn cascade imination annulation cyanation palladium catalyst and other aspects.Application of 157869-15-3
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