Month: October 2022

Haydl, Alexander M.; Hartwig, John F. published the artcile< Palladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters>, Quality Control of 190788-60-4, the main research area is palladium catalyzed methylation aryl heteroaryl boronate ester iodomethane; methylated arene heterocycle preparation palladium catalyzed methylation.

A method for the direct methylation of aryl, heteroaryl, and vinyl boronate esters is reported, involving the reaction of iodomethane with aryl-, heteroaryl-, and vinylboronate esters catalyzed by palladium and PtBu2Me. This transformation occurs with a remarkably broad scope and is suitable for late-stage derivatization of biol. active compounds via the boronate esters. The unique capabilities of this method are demonstrated by combining carbon-boron bond-forming reactions with palladium-catalyzed methylation in a tandem transformation.

Organic Letters published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation) (methylated). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Quality Control of 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yi, Xuewen; Lei, Siyu; Liu, Wangsheng; Che, Fengrui; Yu, Chunzheng; Liu, Xuesong; Wang, Zonghua; Zhou, Xin; Zhang, Yuexia published the artcile< Copper-Catalyzed Radical N-Demethylation of Amides Using N-Fluorobenzenesulfonimide as an Oxidant>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is copper catalyzed radical demethylation amide fluorobenzenesulfonimide.

An unprecedented N-demethylation of N-Me amides has been developed by use of N-fluorobenzenesulfonimide as an oxidant with the aid of a copper catalyst. The conversion of amides to carbinolamines involves successive single-electron transfer, hydrogen-atom transfer, and hydrolysis, and is accompanied by formation of N-(phenylsulfonyl)benzenesulfonamide. Carbinolamines spontaneously decompose to N-demethylated amides and formaldehyde, because of their inherent instability.

Organic Letters published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (N-Me). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cano, Carolina; Pavon, Javier; Serrano, Antonia; Goya, Pilar; Paez, Juan Antonio; Rodriguez de Fonseca, Fernando; Macias-Gonzalez, Manuel published the artcile< Novel Sulfamide Analogs of Oleoylethanolamide Showing In Vivo Satiety Inducing Actions and PPARα Activation>, Electric Literature of 10305-42-7, the main research area is sulfamide oleoylethanolamide analog preparation peroxisome proliferator activated receptor.

Long chain saturated and unsaturated alkyl sulfamide and Pr sulfamide derivatives, analogs of oleoylethanolamide, were synthesized and evaluated in vivo and in vitro as peroxisome proliferator activated receptor alpha (PPARα) activators. Addnl., the anorexic effects of the new compounds were studied in vivo in food-deprived rats. Among the active compounds N-octadecyl-N’-propylsulfamide was identified as a potent hypolipidemic compound, a potent feeding suppressant, and a concentration-dependent activator of PPARα.

Journal of Medicinal Chemistry published new progress about Peroxisome proliferator-activated receptor α Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Electric Literature of 10305-42-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Josse, Pierre; Allain, Magali; Calupitan, Jan Patrick; Jiang, Yue; Cabanetos, Clement; Roncali, Jean published the artcile< Structural Control of the Molecular Packing and Dynamics of Mechanofluorochromic Materials Based on Small Donor-Acceptor Systems with Turn-On Luminescence>, Quality Control of 6482-24-2, the main research area is mechanofluorochromic mol packing luminescence density functional theory.

A series of simple donor-acceptor mols. consisting of an oligo-oxyethylene (OOE) N-substituted diphenylamine connected to a dicyanovinyl (DCV) acceptor group by a thienyl π-conjugating spacer are synthesized. Amorphous deep-red freshly cast thin films rapidly evolve towards an almost colorless pale beige poly-crystalline stable material from which a deep-red photoluminescent state can be switched-on by mech. stimulation. The effects of the length of the OOE chain on the mol. packing of the material and on the dynamics of the recovery process and aggregation in solution are analyzed. Crystallog. results show that the length of the OOE chain directly controls the mol. packing from head-to-tail arrangement of the dipoles for short chain to co-facial dimers leading to a non-centrosym. material with nonlinear optics (NLO) activity for the longer ones. The anal. of the dynamics of the self-recovery process of thin films and of mol. aggregation in solution shows that the dynamics of both processes is directly controlled by the length of the OOE chain. Since, as confirmed by optical and electrochem. results, the OOE substituents have strictly no influence on the electronic properties of the π-conjugated system, the observed effects are unambiguously related to changes in intermol. interactions.

Advanced Optical Materials published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Quality Control of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Simon, Marc-Olivier; Girard, Simon A.; Li, Chao-Jun published the artcile< Catalytic Aerobic Synthesis of Aromatic Ethers from Non-Aromatic Precursors>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is cyclohexenone alc copper catalyzed aerobic oxidative condensation; aryl ether preparation.

Aryl ether formation is accomplished by oxidative condensation of alcs. and 2-cyclohexenones. The reaction complements the existing methods used by synthetic chemists to obtain aryl ethers, and allows a straightforward access to a wide range of functionalized products. In addition, the catalytic reaction with O2 as the oxidant generates water as the only byproduct and provides a “”greener”” approach to aryl ethers.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Jun; Peng, Chao; Yao, Bolin; Xu, Hua-Jian; Xie, Qiang published the artcile< Direct Deoxyfluorination of Alcohols with KF as Fluorine Source>, Quality Control of 52244-70-9, the main research area is triflate preparation; alc direct deoxyfluorination potassium fluoride transition metal free.

This report described a method for the deoxyfluorination of alcs. with KF as fluorine source via in situ generation of highly active CF3SO2F. Diverse functionalities including halogen, nitro, ketone, ester, alkene and alkyne are well tolerated. Mild condition, short reaction time and wide substrate scope enable this method an excellent choice for the construction of C-F bonds.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bach, Anders; Pizzirani, Daniela; Realini, Natalia; Vozella, Valentina; Russo, Debora; Penna, Ilaria; Melzig, Laurin; Scarpelli, Rita; Piomelli, Daniele published the artcile< Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies>, SDS of cas: 52244-70-9, the main research area is benzoxazolone carboxamide preparation SAR acid ceramidase inhibitory anticancer.

Ceramides are lipid-derived intracellular messengers involved in the control of senescence, inflammation, and apoptosis. The cysteine amidase, acid ceramidase (AC), hydrolyzes these substances into sphingosine and fatty acid and, by doing so, regulates their signaling activity. AC inhibitors may be useful in the treatment of pathol. conditions, such as cancer, in which ceramide levels are abnormally reduced. Here, we present a systematic SAR investigation of the benzoxazolone carboxamides, a recently described class of AC inhibitors that display high potency and systemic activity in mice. We examined a diverse series of substitutions on both benzoxazolone ring and carboxamide side chain. Several modifications enhanced potency and stability, and one key compound with a balanced activity-stability profile I was found to inhibit AC activity in mouse lungs and cerebral cortex after systemic administration. The results expand our arsenal of AC inhibitors, thereby facilitating the use of these compounds as pharmacol. tools and their potential development as drug leads.

Journal of Medicinal Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, SDS of cas: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Flippin, Lee A.; Berger, Jacob; Parnes, Jason S.; Gudiksen, Mark S. published the artcile< Effect of the Substitution Pattern on Reactions of Methoxylated Araldehyde 2,4-Dimethyl-3-pentylimines with Organolithium Reagents>, Recommanded Product: 3-Methoxy-2-methylbenzaldehyde, the main research area is methoxyphenylmethylenepentanamine butylation phenylation; substitution effect lithiation araldehyde methylpentylimine; metalation regioselective araldimine; imine methoxybenzaldehyde lithiation substitution effect.

Araldehyde imines, e.g., N-[(methoxyphenyl)methylene]dimethyl-3-pentanamines I (R, R1, R2 = H, OMe) reacted with BuLi via facile nucleophilic aromatic substitution to give benzaldehydes II. Exceptions to this trend were observed when the araldimine substrate contained methoxy groups at both C-2 and C-5. Thus, the 2,5-dimethoxy analog of I reacted with BuLi – followed by MeI quench and acid hydrolysis – to give a complex aldehyde mixture derived from metalation and SNAr processes, e.g. 3,6-dimethoxy-2-methylbenzaldehyde and 2-butyl-5-methoxybenzaldehyde, whereas the 2,4,5-trimethoxy analog of I under identical conditions, gave exclusive metalation and electrophilic capture at C-6 to give 3,4,6-trimethoxy-2-methylbenzaldehyde in 83% yield. Araldehyde 2,4-dimethyl-3-pentylimines that cannot undergo an SNAr reaction are potential candidates for directed metalation reactions although this usage is limited by occasional unwanted side-reactions, lack of selectivity or reactivity, and unpredictability.

Journal of Organic Chemistry published new progress about Alkylation. 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, Recommanded Product: 3-Methoxy-2-methylbenzaldehyde.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Peng; Chen, Shuqing; Zhou, Zhiyu; Cheng, Hong-Gang; Zhou, Qianghui published the artcile< Chemoselective Borono-Catellani Arylation for Unsymmetrical Biaryls Synthesis>, Quality Control of 190788-60-4, the main research area is biaryl alkene alkenoate chemoselective diastereoselective preparation; palladium norbornenedicarboxylate catalyst borono Catellani reaction; chemoselective stereoselective arylation arylpinacolboronate bromoarene alkene palladium norbornenedicarboxylate catalyst.

In the presence of Pd(OAc)2 and a norbornenedicarboxylate, arylpinacolboronates such as 2-methylphenyl pinacolboronate underwent chemoselective aerobic borono-Catellani reactions with aryl bromides such as Me 2-bromobenzoate and alkenes (including α,β-unsaturated esters) such as tert-Bu acrylate to yield unsym. biaryl alkenes such as biphenylpropenoate I. In the absence of alkene, a bromophenylcarbamate underwent coupling and cyclization with 2-naphthylpinacolboronate to yield a mixture of benzocarbazoles in 45% combined yield; a bromophenol underwent coupling without cyclization.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Quality Control of 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Junjun; Hua, Kaimin; Liu, Xiaofang; Deng, Yuchao; Wei, Baiyin; Wang, Hui; Sun, Yuhan published the artcile< Selective Production of Linear Aldehydes and Alcohols from Alkenes using Formic Acid as Syngas Surrogate>, Quality Control of 52244-70-9, the main research area is alkene formic acid rhodium regioselective hydroformylation catalyst; aldehyde linear preparation; formic acid alkene rhodium Shvo regioselective hydroxymethylation catalyst; alc linear preparation; formic acid; hydroformylation; hydroxymethylation; linear alcohol; tandem reaction.

Performing carbonylation without the use of carbon monoxide for high-value-added products is an attractive yet challenging topic in sustainable chem. Herein, effective methods for producing linear aldehydes or alcs. selectively with formic acid as both carbon monoxide and hydrogen source have been described. Linear-selective hydroformylation of alkenes proceeds smoothly with up to 88% yield and >30 regioselectivity in the presence of single Rh catalyst. Strikingly, introducing Ru into the system, the dual Rh/Ru catalysts accomplish efficient and regioselective hydroxymethylation in one pot. The present processes utilizing formic acid as syngas surrogate operate simply under mild condition, which opens a sustainable way for production of linear aldehydes and alcs. without the need for gas cylinders and autoclaves. As formic acid can be readily produced via CO2 hydrogenation, the protocols represent indirect approaches for chem. valorization of CO2.

Chemistry – A European Journal published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem