Month: October 2022

Zhen, Long; Fan, Hui; Wang, Xiaoji; Jiang, Liqin published the artcile< Synthesis of Thiocarbamoyl Fluorides and Isothiocyanates Using CF3SiMe3 and Elemental Sulfur or AgSCF3 and KBr with Amines>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is thiocarbamoyl fluoride isothiocyanate preparation amine sulfur trifluoromethyl trimethylsilane.

Reactions of thiocarbonyl fluoride derived from cheap, readily available, and widely used CF3SiMe3, elemental sulfur, and KF with secondary amines and primary amines at room temperature in THF provided a wide variety of thiocarbamoyl fluorides and isothiocyanates in moderate to excellent yields, resp. The two reactions show broad substrate scope and good functional group tolerance. Moreover, AgSCF3 reacts with secondary/primary amines under KBr at room temperature, affording quant. thiocarbamoyl fluorides/isothiocyanates, which feature late-stage application.

Organic Letters published new progress about Fluorides Role: SPN (Synthetic Preparation), PREP (Preparation) (thiocarbamoyl). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Feng, Shao-Ping; Huang, Kun published the artcile< Enhanced separation of Pd(II) and Pt(IV) from hydrochloric acid aqueous solution using 2-((2-methoxyethyl)thio)-1H-benzimidazole>, Synthetic Route of 6482-24-2, the main research area is palladium platinum separation extraction methoxyethyl thiobenzimidazole.

Separation of palladium (Pd) and platinum (Pt) by solvent extraction is difficult because of their extremely similar physicochem. properties. Development of new extractants with a high extraction efficiency and excellent separation selectivity is the primary focus for enhancing the separation of Pd and Pt by solvent extraction In this study, a new extractant, 2-((2-methoxyethyl)thio)-1H-benzimidazole (MOBI), which contains N, S, and O atoms, was synthesized and used to sep. Pd(II) and Pt(IV) from a hydrochloric acid aqueous solution The exptl. results revealed that Pd(II) and Pt(IV) were effectively separated under the optimal conditions: MOBI concentration of 0.005 mol·L-1, HCl concentration of 0.2 mol·L-1, organic/aqueous (O/A) phase ratio of 1.0, and contact time of 15 min. The separation coefficient between Pd(II) and Pt(IV) was 1246.40, which indicates that MOBI has a higher selectivity for Pd(II) than Pt(IV). In addition, the mechanism of coordination between Pd(II) and MOBI was demonstrated through the slope method, Fourier transform IR spectroscopy (FTIR), hydrogen-1 NMR spectroscopy (1H NMR), and carbon-13 NMR spectroscopy (13C NMR). The results revealed that MOBI could coordinate with Pd(II) via the N atom in the benzimidazole ring of MOBI mols. to form [Pd(MOBI)2Cl2](O).

Rare Metals (Beijing, China) published new progress about Extraction (stripping). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Synthetic Route of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shinohara, Koichi; Tsurugi, Hayato; Mashima, Kazushi published the artcile< N-Methylation of Aniline Derivatives with CO2 and Phenylsilane Catalyzed by Lanthanum Hydridotriarylborate Complexes bearing a Nitrogen Tridentate Ligand>, Product Details of C8H11NO, the main research area is methyl aniline preparation; aniline methylation phenylsilane lanthanum hydridotriarylborate complex nitrogen tridentate ligand; lanthanum hydridotriarylborate complex nitrogen tridentate ligand preparation.

A lanthanum amide complex, La(L)[N(SiHMe2)2](thf) (L = N,N””-bis(pentafluorophenyl)diethylenetriamine dianion), upon activation with B(3,4,5-F2C6H2)3, showed excellent catalytic activity for N-methylation of N-alkylaniline derivatives with CO2 in the presence of PhSiH3. A catalytically active lanthanum hydridotriarylborate complex, [La(L)(thf)2][HB(3,4,5-F3C6H2)3], was generated via hydride abstraction from the Si-H moiety by moderate Lewis acid B(3,4,5-F2C6H2)3 in THF. DFT studies of the CO2 hydrosilylation step clarified the following multiple noncovalent interactions as key factors for locating the HB(3,4,5-F2C6H2)3 anion and B(3,4,5-F3C6H2)3 near the lanthanum center in the transition states of CO2 reduction and Si-O bond formation: (1) π-π interaction between the electron-deficient C6F5 ring on ligand L and the 3,4,5-F3C6H2 ring of the HB(3,4,5-F3C6H2)3 anion and (2) C-H···F hydrogen bonds between the ortho-C-H bond of B(3,4,5-F3C6H2)3 and the fluorine atoms of L.

ACS Catalysis published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xin, Zhili; Himmelbauer, Martin K.; Jones, J. Howard; Enyedy, Istvan; Gilfillan, Rab; Hesson, Thomas; King, Kristopher; Marcotte, Douglas J.; Murugan, Paramasivam; Santoro, Joseph C.; Gonzalez-Lopez de Turiso, Felix published the artcile< Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors>, Computed Properties of 6482-24-2, the main research area is preparation CNS penetrant apoptosis signal regulating kinase inhibitor.

Apoptosis signal-regulating kinase 1 (ASK1) is a key mediator in the apoptotic and inflammatory cellular stress response. To investigate the therapeutic value of modulating this pathway in neurol. disease, we have completed medicinal chem. studies to identify novel CNS-penetrant ASK1 inhibitors starting from peripherally restricted compounds reported in the literature. This effort led to the discovery of 21, a novel ASK1 inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat Kp,uu = 0.38).

ACS Medicinal Chemistry Letters published new progress about Apoptosis. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Computed Properties of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bhatthula, Bharath Kumar Goud; Kanchani, Janardhan Reddy; Arava, Veera Reddy; Subha, M. C. S. published the artcile< Total synthesis of carbazole alkaloids>, Reference of 190788-60-4, the main research area is carbazole alkaloid total synthesis Suzuki Miyaura cross coupling; Cadogan reductive cyclization total synthesis carbazole alkaloid.

A Suzuki-Miyaura cross coupling, followed by triphenylphosphine mediated Cadogan reductive cyclization sequence provided efficient access to a series of carbazole alkaloids. In the present work, this approach was applied to the total synthesis of mukonine, clauszoline K, koenoline, murrayanine, murrayafoline A, mukoeic acid, glycoborine, glycozolicine, mukolidine, mukoline, glycozoline, 3-methoxy-9H-carbazole-1-carboxylic acid Me ester, (3-methoxy-9H-carbazol-1-yl)-methanol, 3-methoxy-9H-carbazole-1-carbaldehyde, 3-methoxy-9H-carbazole-1-carboxylic acid, 2-methyl-9H-carbazole and nonsteroidal anti-inflammatory drug (NSAID) carprofen and its derivatives

Tetrahedron published new progress about Cadogan reaction. 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Reference of 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Rui; Gong, Zhong-Liang; Zhu, Qijian; Sun, Meng-Jia; Che, Yanke; Yao, Jiannian; Zhong, Yu-Wu published the artcile< A pre-organized monomer-reservoir strategy to prepare multidimensional phosphorescent organoplatinum nanocrystals and suprastructures>, SDS of cas: 6482-24-2, the main research area is phosphorescent organoplatinum nanocrystal suprastructure.

The preparation of multidimensional nano- and micro structures, in particular suprastructures with well-defined morphol. and bright emissions, is a challenging task in supramol. assembly. For this purpose, a new type of amphiphilic diplatinum complexes is presented as an excellent building block to assemble into highly phosphorescent nanofibers by supramol. Pt···Pt interactions. These organoplatinum supramol. fibers are further used as a pre-organized monomer reservior for the metal ion-triggered post-transformation into crystalline nanoneedles, nanorods, nanobunches, microplates, and microflowers with controllable morphol. and bright phosphorescence. A reverse transformation of the obtained nanorods into nanofibers is demonstrated with the aid of ethylenediamine tetraacetic acid. In contrast, the direct treatment of diplatinum complexes with different metal ions fails to give well-defined nano and microstructures, suggestive of the pre-organized role of nanofibers for the morphol. transformation. Preliminary applications of these nano- and suprastructures in sensing temperature and organic vapors by emission signal changes are demonstrated. In contrast to the conventional hierarchical assembly, the pre-organized monomer-reservoir strategy disclosed in this study offers a versatile method for the synthesis of organic nano and suprastructures with multidimensional morphol. and controllable emission properties.

Science China: Chemistry published new progress about Crystallinity. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, SDS of cas: 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mizoguchi, Haruki; Seriu, Masaya; Sakakura, Akira published the artcile< Synthesis of functionalized cyclopropylboronic esters based on a 1,2-metallate rearrangement of cyclopropenylboronate>, Category: ethers-buliding-blocks, the main research area is crystal structure mol optimized seleno cyclopropyl boronic ester preparation; stereoselective metalate rearrangement cyclopropenyl boronate.

A procedure converting tribromocyclopropane to densely functionalized β-selenocyclopropylboronic ester using the 1,2-metalate rearrangement of a boron ate-complex has been developed. Treatment of an in situ-generated cyclopropenylboronic ester ate-complex with phenylselenenyl chloride triggered stereospecific rearrangement to produce functionalized cyclopropanes. DFT calculations for 1,2-metalate rearrangement suggested that the reaction proceeds through a seleniranium intermediate.

Chemical Communications (Cambridge, United Kingdom) published new progress about Boronic acids, esters Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (cyclopropyl). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Karmakar, Ujjwal; Hwang, Ho Seong; Lee, Yunjeong; Cho, Eun Jin published the artcile< Photocatalytic para-Selective C-H Functionalization of Anilines with Diazomalonates>, Synthetic Route of 10541-78-3, the main research area is photocatalytic para selective alkylation aniline diazomalonate.

Visible-light-induced para-selective C-H functionalization of anilines over N-H insertion was developed using diazomalonates with the help of an Ir(III) photocatalyst. The para-selective radical-radical cross coupling proceeded via C-centered radical intermediates generated from both anilines and diazomalonates. The photochem. of anilines could be extended to other N-heterocycles, such as indole and carbazole. The reaction pathway for the selective C-C coupling was validated by electrochem. and photophys. experiments as well as computational studies.

Organic Letters published new progress about Alkylation, regioselective (photocatalytic). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Synthetic Route of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xing, Nannan; Niu, Kaixuan; Liu, Kefeng; Fang, Dawei; Ma, Xiaoxue; Guan, Wei; Yang, Jiazhen published the artcile< The molar surface quasi-Gibbs energy and its application to the binary mixtures of 1-(2-methoxyethyl)-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide [MOEMIM][NTf2] with methanol and ethanol>, Category: ethers-buliding-blocks, the main research area is molar surface Gibbs energy sulfonylimide methanol ethanol binary mixture.

The IL (ionic liquid) 1-(2-methoxyethyl)-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide [MOEMIM][NTf2] was prepared and confirmed by 1H NMR (1H NMR) spectroscopy and 13C NMR (13C NMR) spectroscopy. The d. and surface tension for the binary mixtures of [MOEMIM][NTf2] with methanol and ethanol were measured across the entire range of mole fraction (x1 = 0.0000-1.0000) at T = (288.15-318.15) K. The average molar volumes of the binary mixtures were calculated from the exptl. d., which increased with the increase of mole fraction and temperature The excess molar volumes, VEm, were obtained and fitted by Redlich-Kister equation. The interaction between ionic liquid and alc. is the strongest efficient packing and/or attractive interaction at the min. point. The lower the temperature was, the smaller the absolute value of excess molar volume was. The new function – the molar surface quasi-Gibbs energy of mixtures was obtained by us in this work. On a basis of molar surface quasi-Gibbs energy of mixtures, a new Eotvos equation was obtained of mixtures and applied to binary mixtures of [MOEMIM][NTf2] with alcs. The absolute value of the slope of the new Eotvos equation is the mole surface entropy, s, and the intercept is the molar surface enthalpy, h, which is temperature-independent. The deviation of molar surface quasi-Gibbs energy, Δgs, of mixtures for [MOEMIM][NTf2] with methanol and ethanol were calculated Δgs was well fitted by Redlich-Kister equation. In terms of Redlich-Kisters parameters, Ai, a new method for estimating the surface tension, γ, with any component of the mixtures is proposed and the estimated values, γ (estimate), are in good agreement with the corresponding exptl. ones, γ(exp.).

Journal of Chemical Thermodynamics published new progress about Binary mixtures, liquid. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jiang, Xiaohuan; Deng, Zhijie; Tang, Pingping published the artcile< Direct Dehydroxytrifluoromethoxylation of Alcohols>, Application In Synthesis of 52244-70-9, the main research area is trifluoromethyl alkyl ether chemoselective preparation; etherification alc trifluoromethyl toluenesulfonate mediated cesium fluoride; dehydroxytrifluoromethylation primary secondary alc trifluoromethyl toluenesulfonate; fluoroformate intermediate dehydroxytrifluoromethylation alc trifluoromethyl toluenesulfonate; alcohols; nucleophilic substitution; synthetic methods; trifluoromethoxylation; trifluoromethyl arylsulfonate.

Primary alcs. and selected secondary alcs. underwent chemoselective direct dehydroxytrifluoromethoxylation with trifluoromethyl p-toluenesulfonate mediated by CsF and tetramethylammonium bromide in HMPA/DMA at 30-100° to yield trifluoromethyl ethers. The trifluoromethylation reaction is operationally simple and scalable, and proceeds under mild reaction conditions to provide access to a wide range of trifluoromethyl ethers from alcs.; functionalized natural products such as a deoxycholic acid-derived triol and pleuromutilin were also used as substrates.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem