Month: October 2022

Xie, Qiqiang; Dong, Guangbin published the artcile< Programmable Ether Synthesis Enabled by Oxa-Matteson Reaction>, Recommanded Product: 2-(2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the main research area is boronate alkyl aryl oxa Matteson oxygen carbenoid insertion reaction; boron substituted ether product preparation.

The Matteson-type reactions have received increasing interest in constructing complex organic mols. via iterative synthetic strategies; however, the current tactics are almost exclusively based on homologation of pure C chains. Here, the authors report the development of the oxa-Matteson reaction that enables sequential O and carbenoid insertions into diverse alkyl- and arylboronates. It offers a distinct entry to a wide range of B-substituted ethers. The utilities of this method are demonstrated in the preparation of various functional ethers, the asym. synthesis of an acetyl-CoA-carboxylase inhibitor, and the programmable construction of polyethers.

Journal of the American Chemical Society published new progress about Boronic acids, esters Role: RCT (Reactant), RACT (Reactant or Reagent) (alkyl and aryl). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Recommanded Product: 2-(2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Marro, Nicolas; della Sala, Flavio; Kay, Euan R. published the artcile< Programmable dynamic covalent nanoparticle building blocks with complementary reactivity>, Related Products of 6482-24-2, the main research area is dynamic covalent nanoparticle monolayer complementary reactivity kinetics.

Nanoparticle-based devices, materials and technologies will demand a new era of synthetic chem. where predictive principles familiar in the mol. regime are extended to nanoscale building blocks. Typical covalent strategies for modifying nanoparticle-bound species rely on kinetically controlled reactions optimized for efficiency but with limited capacity for selective and divergent access to a range of product constitutions. In this work, monolayer-stabilized nanoparticles displaying complementary dynamic covalent hydrazone exchange reactivity undergo distinct chemospecific transformations by selecting appropriate combinations of ‘nucleophilic’ or ‘electrophilic’ nanoparticle-bound monolayers with nucleophilic or electrophilic mol. modifiers. Thermodynamically governed reactions allow modulation of product compositions, spanning mixed-ligand monolayers to exhaustive exchange. High-d. nanoparticle-stabilizing monolayers facilitate in situ reaction monitoring by quant. 19F NMR spectroscopy. Kinetic anal. reveals that hydrazone exchange rates are moderately diminished by surface confinement, and that the magnitude of this effect is dependent on mechanistic details: surface-bound electrophiles react intrinsically faster, but are more significantly affected by surface immobilization than nucleophiles. Complementary nanoparticles react with each other to form robust covalently connected binary aggregates.

Chemical Science published new progress about Aggregation. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Related Products of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sherman, E. S.; Chemler, S. R. published the artcile< Product class 12: N-Alkylsulfamic acid derivatives>, Safety of n-Propylsulphamoyl chloride, the main research area is review alkylsulfamic acid derivative preparation organic synthesis.

A review of methods to prepare N-alkylsulfamic acid derivatives

Science of Synthesis published new progress about Organic synthesis. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Safety of n-Propylsulphamoyl chloride.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Albiniak, Philip A.; Amisial, Shawn M.; Dudley, Gregory B.; Hernandez, Joseph P.; House, Sarah E.; Matthews, Margaret E.; Nwoye, Ernest O.; Reilly, Maureen K.; Tlais, Sami F. published the artcile< Stable oxypyridinium triflate (OPT) salts for the synthesis of halobenzyl ethers>, HPLC of Formula: 52244-70-9, the main research area is pyridinium triflate halobenzyloxy preparation benzylation alc; ether halobenzyl preparation.

A collection of new 2-arylmethoxy-1-methylpyridinium triflate reagents (aryl = 4-BrC6H4, 4-ClC6H4, 4-IC6H4, 2-BrC6H4) for the synthesis of halobenzyl ethers ROCH2Ar [R = Ph(CH2)3, 4-MeOC6H4(CH2)4, 1-adamantyl, (R)-MeO2CCHMeCH2, 5α-cholester-3β-yl] from alcs. ROH under mix-and-heat conditions is described. The reagents are stable organic salts that can be stored indefinitely and handled without special precautions, making them attractive for general use in organic synthesis. Halobenzylation of representative alcs. occurs in good to excellent yields.

Synthetic Communications published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, HPLC of Formula: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Luridiana, Alberto; Mazzarella, Daniele; Capaldo, Luca; Rincon, Juan A.; Garcia-Losada, Pablo; Mateos, Carlos; Frederick, Michael O.; Nuno, Manuel; Jan Buma, Wybren; Noel, Timothy published the artcile< The Merger of Benzophenone HAT Photocatalysis and Silyl Radical-Induced XAT Enables Both Nickel-Catalyzed Cross-Electrophile Coupling and 1,2-Dicarbofunctionalization of Olefins>, Application of C3H7BrO, the main research area is alkyl bromide bromobenzene nickel catalyst photocatalyst reductive cross coupling; alkene alkylbromide bromobenzene nickel catalyst photocatalyst reductive cross coupling; alkylbenzene preparation.

A strategy for both cross-electrophile coupling and 1,2-dicarbofunctionalization of olefins was developed. Carbon-centered radicals were generated from alkyl bromides by merging benzophenone hydrogen atom transfer (HAT) photocatalysis and silyl radical-induced halogen atom transfer (XAT) and were subsequently intercepted by a nickel catalyst to forge the targeted C(sp3)-C(sp2) and C(sp3)-C(sp3) bonds. The mild protocol was fast and scalable using flow technol., displays broad functional group tolerance and was amenable to a wide variety of medicinally relevant moieties. Mechanistic investigations revealed that the ketone catalyst, upon photoexcitation, was responsible for the direct activation of the silicon-based XAT reagent (HAT-mediated XAT) that furnishes the targeted alkyl radical and was ultimately involved in the turnover of the nickel catalytic cycle.

ACS Catalysis published new progress about Alkylbenzenes Role: SPN (Synthetic Preparation), PREP (Preparation). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Application of C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Koch, Vanessa; Brase, Stefan published the artcile< An Intramolecular Iodine-Catalyzed C(sp3)-H Oxidation as a Versatile Tool for the Synthesis of Tetrahydrofurans>, Product Details of C11H16O2, the main research area is THF preparation regioselective; alc carbon hydrogen activation oxidation cyclization iodine catalyst.

The formation of ubiquitous occurring THF patterns has been extensively investigated in the 1960s as it was one of the first examples of a non-directed remote C-H activation. These approaches suffer from the use of toxic transition metals in overstoichiometric amounts An attractive metal-free solution for transforming carbon-hydrogen bonds into carbon-oxygen bonds lies in applying economically and ecol. favorable iodine reagents. The presented method involves an intertwined catalytic cycle of a radical chain reaction and an iodine(I/III) redox couple by selectively activating a remote C(sp3)-H bond under visible-light irradiation The reaction proceeds under mild reaction conditions, is operationally simple and tolerates many functional groups giving fast and easy access to different substituted tetrahydrofurans.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Xiaojuan; Liang, Jinying published the artcile< Alum: an efficient catalyst for trimethylsilylation of alcohols and phenols with hexamethyldisilazane>, Synthetic Route of 52244-70-9, the main research area is trimethylsilylation alc alum catalyst green chem hexamethyldisilazane.

A highly convenient method for the trimethylsilylation of alcs. and phenols via treatment by hexamethyldisilazane in the presence of alum as a catalyst has been developed. A wide variety of hydroxyl groups were selectively protected in CH3CN under mild conditions.

Asian Journal of Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Synthetic Route of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Aikawa, Haruo; Tago, Sakie; Umetsu, Kazuteru; Haginiwa, Naomichi; Asao, Naoki published the artcile< Gold-catalyzed substitution reaction with ortho-alkynylbenzoic acid alkyl ester as an efficient alkylating agent>, Name: 4-(4-Methoxyphenyl)-1-butanol, the main research area is alkynylbenzoic acid alkyl ester alc gold etherification; ether preparation; gold etherification catalyst; alkylating agent alkynylbenzoic acid alkyl ester.

Ortho-Alkynylbenzoic acid alkyl esters behave as alkylating agents in combination with gold catalysts. The reaction with alcs. occurs smoothly in the presence of catalytic amounts of Ph3PAuCl and AgOTf under mild conditions to produce the corresponding ether products in high yields. The protocol is also useful for Friedel-Crafts alkylation and N-alkylation of sulfonamides. The reaction likely proceeds through the gold-induced in situ construction of leaving groups and subsequent nucleophilic attack of nucleophiles, such as alcs., aromatic compounds, and sulfonamides.

Tetrahedron published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Name: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mamidala, Ramesh; Biswal, Priyabrata; Subramani, M. Siva; Samser, Shaikh; Venkatasubbaiah, Krishnan published the artcile< Palladacycle-Phosphine Catalyzed Methylation of Amines and Ketones Using Methanol>, Application of C8H11NO, the main research area is amine ketone methylation palladacycle phosphine catalyst methanol.

Methylation of amines and ketones with palladacycle precatalyst was performed using methanol as an environmentally benign reagent. Various ketones and amines undergo methylation reaction to yield monomethylated amines or ketones in moderate to good isolated yields. Moreover, this protocol was tested for the chemoselective methylation of 4-aminobenzenesulfonamide. The scope of the reaction was further extended to the deuteromethylation of ketones.

Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pelter, Andrew; Ward, Robert S.; Rao, Ramohan R. published the artcile< An approach to the biomimetic synthesis of aryltetralin lignans>, HPLC of Formula: 52244-70-9, the main research area is methoxyphenylpropylquinonemethide ketal cyclization; quinonemethide ketal methoxyphenylpropyl cyclization; anisyltetralin; tetralin anisyl.

The aryltetralins I (R = H, R1 = R2 = H, OMe; R = R1 = OMe, R2 = H) were prepared from the corresponding 2,3,5,4-RR1R2(MeO)C6H(CH2)3CO2H in 6 steps, the key step being the biomimetic cyclization of the quinonemethide ketals II to I on treatment with BF3.Et2O.

Tetrahedron Letters published new progress about 52244-70-9. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, HPLC of Formula: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem