October 2022 - Page 182 of 194 - Ethers-buliding-blocks

Cruz-Migoni, Abimael’s team published research in Proceedings of the National Academy of Sciences of the United States of America in 2019 | CAS: 2398-37-0

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Recommanded Product: 1-Bromo-3-methoxybenzene

Recommanded Product: 1-Bromo-3-methoxybenzeneIn 2019 ,《Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds》 appeared in Proceedings of the National Academy of Sciences of the United States of America. The author of the article were Cruz-Migoni, Abimael; Canning, Peter; Quevedo, Camilo E.; Bataille, Carole J. R.; Bery, Nicolas; Miller, Ami; Russell, Angela J.; Phillips, Simon E. V.; Carr, Stephen B.; Rabbitts, Terence H.. The article conveys some information:

The RAS gene family is frequently mutated in human cancers, and the quest for compounds that bind to mutant RAS remains a major goal, as it also does for inhibitors of protein-protein interactions. We have refined crystallization conditions for KRAS169Q61H-yielding crystals suitable for soaking with compounds and exploited this to assess new RAS-binding compounds selected by screening a protein-protein interaction-focused compound library using surface plasmon resonance. Two compounds, referred to as PPIN-1 and PPIN-2, with related structures from 30 initial RAS binders showed binding to a pocket where compounds had been previously developed, including RAS effector protein-protein interaction inhibitors selected using an intracellular antibody fragment (called Abd compounds). Unlike the Abd series of RAS binders, PPIN-1 and PPIN-2 compounds were not competed by the inhibitory anti-RAS intracellular antibody fragment and did not show any RAS-effector inhibition properties. By fusing the common, anchoring part from the two new compounds with the inhibitory substituents of the Abd series, we have created a set of compounds that inhibit RAS-effector interactions with increased potency. These fused compounds add to the growing catalog of RAS protein-protein inhibitors and show that building a chem. series by crossing over two chem. series is a strategy to create RAS-binding small mols. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 1-Bromo-3-methoxybenzene)

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Almenar, S’s team published research in Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft in 2019 | CAS: 106685-40-9

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application of 106685-40-9

The author of 《Anatomy, immunohistochemistry, and numerical distribution of human splenic microvessels.》 were Almenar, S; Rios-Navarro, C; Ortega, M; Molina, P; Ferrandez-Izquierdo, A; Ruiz-Sauri, A. And the article was published in Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft in 2019. Application of 106685-40-9 The author mentioned the following in the article:

The microvascular architecture of the spleen plays an important role in the immunological function of this organ. The different types of vessels are related to different reticular cells each with their own immunomodulatory functions. The present study describes an immunohistochemical and morphometric analysis of the various types of vessels in 21 human autopsy non-pathological splenic samples. On an area of 785,656.37 μm2 for each sample, we classified and quantified the type and number of vascular structures, each according to their morphology and immunohistochemical profile, and obtained the ratios between them. The distribution of trabecular vessels and the characteristics of the venules are reviewed. In our material the so-called “”cavernous perimarginal sinus”” (anatomical structure previously described by Schmidt et al., 1988) was observed and interpreted as a curvilinear venule shaped by the follicle in contact with the trabecular vein. Our material comprised 261 trabeculae (containing 269 arterial sections and 508 venous sections), 30,621 CD34+ capillaries, 7739 CD271+ sheathed capillaries, 2588 CD169+ sheathed capillaries, and 31,124 CD8+ sinusoids. The total area (TA) (14,765,714.88 μm2) occupied by the sinusoidal sections of the 21 cases was much higher than the TA of the capillary sections (1,700,269.83 μm2). Similarly, the TA (651,985 μm2) occupied by the sections of the trabecular veins was much higher than the TA of the trabecular arteries (88,594 μm2). The total number of CD34+ capillaries and of sinusoids CD8+ was similar for the sum of the 21 cases, nevertheless there were large differences in each case. Statistically the hypothesis that the number of capillaries and sinusoids are present with the same frequency is discarded. In view of the absence of a numerical correlation between capillaries and sinusoids, we postulate that very possibly the arterial and the venous vascular trees are two anatomically independent structures separated by the splenic cords. We believe that this is the first work where splenic microvascularization is simultaneously approached from a morphometric and immunohistochemical point of view. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application of 106685-40-9)

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

More, Vijaykumar’s team published research in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 2020 | CAS: 882-33-7

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Recommanded Product: 882-33-7 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

《KF-Al2O3 catalyzed mild and efficient preparation of symmetrical disulfides from thiols》 was published in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 2020. These research results belong to More, Vijaykumar; Malba, Chandrashekhar; Panchgalle, Sharad. Recommanded Product: 882-33-7 The article mentions the following:

A facile, efficient, convenient and environmentally friendly method for the oxidation of various thiols RCH2SH (R = n-Pr, Ph, 2-furyl, etc.) to their corresponding disulfides (RCH2S)2 catalyzed by KF-Al2O3 in very short reaction times in acetonitrile and at room temperature has been reported. In addition to this study using 1,2-Diphenyldisulfane, there are many other studies that have used 1,2-Diphenyldisulfane(cas: 882-33-7Recommanded Product: 882-33-7) was used in this study.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Manuri, Brahmayya’s team published research in Proceedings of the National Academy of Sciences, India, Section A: Physical Sciences in 2018 | CAS: 33797-34-1

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.SDS of cas: 33797-34-1Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

SDS of cas: 33797-34-1On March 31, 2018, Manuri, Brahmayya; Dasi, Samsonu; Korla, Praveen Kumar published an article in Proceedings of the National Academy of Sciences, India, Section A: Physical Sciences. The article was 《Neat Synthesis of Substituted Benzoic Acids Employing TBHP/Oxone Catalyst and Study of Their Anti-oxidant Activity》. The article mentions the following:

In the present study, a variety of benzyl alcs. are synthesized from corresponding benzoic acids employing TBHP/oxone and FeCl3 as an effective and selective catalyst under solvent free conditions. The conversion rate and yields of the products are significant. The advantages of the selected catalyst are: cheaply available and more selectivity of the product formations rather than the formation of any undesired byproducts. The synthesized compounds were tested for anti-oxidant activities. In the experiment, the researchers used (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1SDS of cas: 33797-34-1)

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhao, Xin’s team published research in ACS Catalysis in 2022-02-04 | 10541-78-3

ACS Catalysis published new progress about Amination catalysts (stereoselective, regioselective). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Formula: C8H11NO.

Zhao, Xin; Yang, Fang; Zou, Shao-Yu; Zhou, Qian-Qian; Chen, Zi-Sheng; Ji, Kegong published the artcile< Cu-Catalyzed Intermolecular γ-Site C-H Amination of Cyclohexenone Derivatives: The Benefit of Bifunctional Ligands>, Formula: C8H11NO, the main research area is aniline cyclohexenone copper catalyst regioselective amination green chem; amino alc preparation antibacterial antioxidant; cyclohexadienyl oxy silyl ether aniline copper regioselective diastereoselective amination; aminocyclohexenone preparation green chem.

Utilizing 1,10-phenanthroline-type bifunctional ligands, an efficient Cu-catalyzed intermol. site-selective remote C-H amination using cyclohexenone derivatives and anilines was realized. The amide group installed on the bifunctional ligand played a key role in stabilizing the N-centered radical generated in-situ to realize C-N-directed formation. Meanwhile, a useful catalytic system for site-selective intermol. remote γ-C-H amination to p-aminophenols and γ-aminated enones was established. This economical and practical approach using oxygen as the terminal oxidant was mild and environmentally friendly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wei, Jie’s team published research in Journal of Molecular Liquids in 2020-09-01 | 6482-24-2

Journal of Molecular Liquids published new progress about Activation energy. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Computed Properties of 6482-24-2.

Wei, Jie; Lu, Donghui; Jiang, Cailian; Fang, Dawei; Hu, Xiaohong published the artcile< Experimental determination of viscosity for the binary mixtures of the ether-functionalized ionic liquids [C22O1IM][TfO] with monohydric alcohols>, Computed Properties of 6482-24-2, the main research area is ionic liquid monohydric alc viscosity binary mixture.

In order to apply ionic liquids in various fields, it is necessary to understand their phys. and chem. properties. Viscosity, in particular, is an important parameter of multicomponent solutions and plays a decisive role in mass transfer, heat transfer and fluid flow in industrial process. In this work, the ether-functionalized ionic liquid [C22O1IM][TfO] was synthesized and characterized by 1H NMR, 13C NMR, ESI mass spectrometry and elemental anal. The viscosity of the binary mixture of ionic liquid [C22O1IM][TfO] with ethanol, 1-propanol and 2-propanol in the full concentration range of T = (288.15-318.15) K were measured. The relationships between the viscosity of the binary system and concentration and temperature were investigated. By Vogel-Tamman-Fulcher (VTF) equation and Arrhenius equation, the temperature dependences of the viscosities for the binary system were described and the VTF equation showed better correlation for the binary system. The viscosity deviation that expresses the difference between the actual value and the ideal value of the mixture viscosity, Δη, was calculated At the same time, the Gibbs energy of activation for viscous flow of the relative viscosity for the mixture, ΔG≠r, was also calculated based on the relative viscosity, ηr, and ΔG≠r is neg. that is consistent with the results of, Δη, it means that the interaction between ions becomes weak due to the solvation.

Journal of Molecular Liquids published new progress about Activation energy. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Computed Properties of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lin, Xiao-Long’s team published research in Organic Chemistry Frontiers in 2022 | 6482-24-2

Organic Chemistry Frontiers published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Lin, Xiao-Long; Yu, Yan; Zhang, Liang; Leng, Li-Jing; Xiao, Dong-Rong; Cai, Tian; Luo, Qun-Li published the artcile< Switchable synthesis of 1,4-bridged dihydroisoquinoline-3-ones and isoquinoline-1,3,4-triones through radical oxidation of isoquinolinium salts with phenyliodine(III) diacetate>, Category: ethers-buliding-blocks, the main research area is bridged dihydroisoquinolinone isoquinoline trione preparation stereoselective; isoquinolinium salt hydroxycoumarin radical oxidation annulation.

A metal-free switchable synthesis of 1,4-bridged dihydroisoquinoline-3-ones and isoquinoline-1,3,4-triones through the oxidation of isoquinolinium salts is described. 1,4-Bridged dihydroisoquinolin-3-ones were constructed for the first time via the sequential oxidation/annulation of isoquinolinium salts with 4-hydroxycoumarins. Meanwhile, the iodine(III)-oxidized intermediates of isoquinolinium salt could be converted to isoquinoline-1,3,4-triones in high yields by treatment with tert-Bu hydroperoxide. These site-selective transformations rely on an iodine(III)-mediated dual radical addition/radical coupling strategy and prove that the combination of the bromide anion and phenyliodine(III) diacetate is a useful carrier of relatively stable bromine radicals and highly labile carboxyl radicals.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Spadaro, Angelo’s team published research in Frontiers in Pharmacology in 2020 | 6482-24-2

Frontiers in Pharmacology published new progress about Bovine serum albumin Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Formula: C3H7BrO.

Spadaro, Angelo; Rao, Marco; Lorenti, Miriam; Romano, Mario Rosario; Augello, Antonio; Eandi, Chiara Maria; Platania, Chiara Bianca Maria; Drago, Filippo; Bucolo, Claudio published the artcile< New brilliant blue G derivative as pharmacological tool in retinal surgery>, Formula: C3H7BrO, the main research area is alkyl brilliant blue inner limiting membrane retina vitreoretinal surgery; Brilliant Blue G; drug design; inner limiting membrane; pucker; retina; vitreoretinal surgery.

Our study was aimed at assessing the retinal binding of a new synthetic Brilliant Blue G (BBG) derivative (pure benzyl-Brilliant Blue G; PBB) ophthalmic formulation, to improve vitreoretinal surgery procedure. Protein affinity of the new mol. was evaluated in vitro (cell-free assay) and in silico. Furthermore, an ex vivo model of vitreoretinal surgery was developed by using porcine eyes to assess the pharmacol. profile of PBB, compared to com. formulations based on BBG and methyl-BBG (Me-BBG). PBB showed a higher affinity for proteins (p < 0.05), compared to BBG and Me-BBG. In vitro and in silico studies demonstrated that the high selectivity of PBB could be related to high lipophilicity and binding affinity to fibronectin, the main component of the retinal internal limiting membrane (ILM). The PBB staining capabilities were evaluated in porcine eyes in comparison with BBG and Me-BBG. Forty microliters of each formulation were slowly placed over the retinal surface and removed after 30 s. After that, ILM peeling was carried out, and the retina collected. BBG, Me-BBG, and PBB quantification in ILM and retina tissues was carried out by HPLC anal. PBB levels in the ILM were significantly (p < 0.05) higher compared to BBG and Me-BBG formulations. On the contrary, PBB showed a much lower (p < 0.05) distribution in retina (52 ng/mg tissue) compared to BBG and Me-BBG, in particular PBB levels were significantly (p < 0.05) lower. Therefore, the new synthetic Brilliant Blue derivative (PBB) showed a great ILM selectivity in comparison to underneath retinal layers. In conclusion, these findings had high translational impact with a tangible improving in ex vivo model of retinal surgery, suggesting a future use during surgical practice. Frontiers in Pharmacology published new progress about Bovine serum albumin Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Formula: C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Schenkels, Peter’s team published research in Microbiology (Reading, United Kingdom) in 2000-04-30 | 52244-70-9

Microbiology (Reading, United Kingdom) published new progress about Alcohols Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Schenkels, Peter; Duine, Johannis A. published the artcile< Nicotinoprotein (NADH-containing) alcohol dehydrogenase from Rhodococcus erythropolis DSM 1069: an efficient catalyst for coenzyme-independent oxidation of a broad spectrum of alcohols and the interconversion of alcohols and aldehydes>, Product Details of C11H16O2, the main research area is Rhodococcus alc dehydrogenase NADH oxidation alc aldehyde.

Extracts from benzyl-alc.-grown Rhodococcus erythropolis DSM 1069 showed NAD(P)-independent, N,N-dimethyl-4-nitrosoaniline (NDMA)-dependent alc. dehydrogenase activity. The enzyme exhibiting this activity was purified to homogeneity and characterized. It appears to be a typical nicotinoprotein as it contains tightly bound NADH acting as cofactor instead of coenzyme. Other characteristics indicate that it is highly similar to the known nicotinoprotein alc. dehydrogenase (np-ADH) from Amycolatopsis methanolica: it is a homotetramer of 150 kDa; N-terminal amino acid sequencing (22 residues) showed that 77% of these amino acids are identical in the two enzymes; it has optimal activity at pH 7.0; it lacks NAD(P)H-dependent aldehyde reductase activity; it catalyzes the oxidation of a broad range of (preferably) primary and secondary alcs., either aliphatic or aromatic, and formaldehyde, with the concomitant reduction of the artificial electron acceptor NDMA. NDMA could be replaced by an aldehyde, but not formaldehyde, the substrate specificity of the enzyme for the aldehydes reflecting that for the corresponding alcs. The latter also applied to the low aldehyde dismutase activity displayed by the enzyme. From this, together with the results of the induction studies, it is concluded that np-ADH functions as the main alc.-oxidizing enzyme in the dissimilation of many, but not all, alcs. by R. erythropolis and may also catalyze coenzyme-independent interconversion of alcs. and aldehydes under certain circumstances. It is anticipated that the enzyme may be of even wider significance since structural data indicate that np-ADH is also present in other (nocardioform) actinomycetes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nishimura, Rodolfo H V’s team published research in Beilstein Journal of Organic Chemistry in 2021 | 10541-78-3

Beilstein Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Nishimura, Rodolfo H. V.; dos Santos, Thiago; Murie, Valter E.; Furtado, Luciana C.; Costa-Lotufo, Leticia V.; Clososki, Giuliano C. published the artcile< Efficient N-arylation of 4-chloroquinazolines en route to novel 4-anilinoquinazolines as potential anticancer agents>, COA of Formula: C8H11NO, the main research area is halophenyl anilinoquinazoline preparation microwave irradiation green chem antitumor human; chloroquinazoline aniline arylation; 4-anilinoquinazoline; 4-chloroquinazoline; N-arylation; anticancer agents; microwave irradiation.

Microwave-mediated N-arylation of 4-chloroquinazolines in THF/H2O rapidly and efficiently afforded a library of novel 6-halo-2-phenyl-substituted 4-anilinoquinazolines. The methodol. was compatible with numerous ortho-, meta-, and para-substituted N-methylanilines as well as substituted anilines and furnished the corresponding 4-anilinoquinazolines in good yields. Preliminary screening of the synthesized compounds against tumor cells (HCT-116 and T98G) showed promising antiproliferative properties.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem