Month: October 2022

《Antibacterial and antifungal study on novel Ag(I)-15C5 complexes》 was published in European Journal of Biomedical and Pharmaceutical Sciences in 2020. These research results belong to Chitlangia, Seema; Ranjan, Rajeev. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane The article mentions the following:

Crown ether is a general name given to macrocyclic polyethers containing ethylene bridges separating electroneg. oxygen atoms. They typically contain central electron rich hydrophilic cavity with diameter varying from 1.2-6.0 Å. Crown ethers have been used for the various studies pertaining to extraction equilibrium constant, stability constant and for determination of some of the alkali and alk. earth elements and other elements from p, d and f-block elements. Crown ethers have a significant coordination power towards silver ion. The present paper describes synthesis, characterization and antimicrobial study of novel Ag(I) complexes synthesized by 15-crown-5 ether. The organic salts used for complexation were salts of nitrophenols. Products were isolated from silver salts of all the three nitrophenols, 2-nitrophenol(ONPH), 2,4-dinitrophenol(DNPH) and 2,4,6-trinitrophenol(TNPH), having general formula of [Ag.L](Pic-), where L = 15C5 and Pic- = Picrate anion. Elemental anal., molar conductivity, UV-Vis, IR, and 1H-NMR spectral anal. were performed for establishment of the structure of synthesized complexes. Antibacterial activities of the synthesized complexes were determined by using Kirby Bauer disk diffusion method. Antibacterial and antifungal activity of the prepared complexes were determined and recorded by zone inhibition method. The experimental part of the paper was very detailed, including the reaction process of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Reference of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《New molecular wires with two ferrocene hinges [Erratum to document cited in CA150:77763]》 was published in Journal of Inorganic and Organometallic Polymers and Materials in 2012. These research results belong to Ma, Jingxiang; Vollmann, Marc; Menzel, Henning; Pohle, Sven; Butenschoen, Holger. Product Details of 74029-40-6 The article mentions the following:

On page 48, the 1H NMR and HRMS data for compound 17 contained errors; the corrected data are given. The experimental process involved the reaction of 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Product Details of 74029-40-6)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Product Details of 74029-40-6 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A colorimetric and near-infrared ratiometric fluorescent probe for hydrazine detection and bioimaging》 was published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020. These research results belong to Wu, Cuiyan; Xie, Ruihua; Pang, Xiao; Li, Yaqian; Zhou, Zile; Li, Haitao. Quality Control of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

Hydrazine (N2H4) is extensively used in industry but highly toxic; hence, highly sensitive detection of N2H4 is extremely meaningful. Herein, a colorimetric and near-IR (NIR) ratiometric fluorescent probe named DXM-OH was rationally designed and synthesized based on oxanthrene malononitrile derivative for the specific detection of N2H4. The dicyanovinyl group in DXM-OH was served as the recognition unit for N2H4. DXM-OH showed high sensitivity to N2H4 in the range of 1-900 μM, with the limit of detection (LOD) of 0.09 μM (2.87 ppb), which is much lower than the U. S. Environmental Protection Agency standard (10 ppb). Furthermore, the practical applications of DXM-OH in detecting N2H4 in real water samples and imaging of N2H4 in living cells were demonstrated, indicating its potential utility for N2H4 sensing in environmental and biol. samples. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Quality Control of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Quality Control of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Comparison of antioxidant activities of mono-, di- and tri-substituted coumarins》 was published in Journal of the Turkish Chemical Society, Section A: Chemistry in 2020. These research results belong to Onar, Hulya Celik; Yasa, Hasniye; Sin, Oktay. HPLC of Formula: 150-19-6 The article mentions the following:

In this study, numerous coumarin compounds I (X = carboxy, acetyl, benzoyl, H; Y = H, Me, Ph, n-propyl; Z = H, hydroxy, amino, methoxy) were synthesized by Pechmann and Knoevenagel methods, and the substitution of the formyl group was provided by the Duff reaction. Besides, the synthesized coumarin derivatives I were compared in terms of antioxidant activity according to DPPH and CUPRAC methods. The main aim of the study is to determine the effects of substituents on antioxidant activity. In the experimental materials used by the author, we found m-Methoxyphenol(cas: 150-19-6HPLC of Formula: 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneHPLC of Formula: 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Simultaneous estimation of dapsone and adapalene in gel formulation by UV- spectroscopy》 was published in International Journal of Pharmaceutical Sciences and Research in 2020. These research results belong to Vichare, V. S.; Handargule, P. V.. Reference of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The article mentions the following:

A new, simple, sensitive, and economical UV spectro-photometric method was developed for the simultaneous anal. of Adapalene and Dapsone in pharmaceutical formulation. This UV method was developed with THF and Distilled water as solvents. The wavelengths selected for anal. in the present method were 237 nm and 293 nm. The method was validated as per ICH guidelines. The method was validated for linearity, accuracy, precision, specificity and robustness. Linearity was found to be within the concentration range of 0.05-0.25μg/mL for Adapalene and 2.5-12.5μg/mL for Dapsone. Accuracy for the method was determined by recovery studies. The % drug recovered was found to be 99-102% weight/weight The % RSD values of repeatability and intermediate precision were found to be less than 2, providing method was precise in nature. From all these studies it was observed that there was no interference of excipients from the formulation during the anal. The advantages of this method for anal. purposes lie in the rapid determination, its cost-effectiveness, easy preparation of the sample and good reproducibility. In addition to this, the present method can be recommended for the simultaneous determination of Adapalene and Dapsone in routine quality control anal. in combined drug formulations. In addition to this study using 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid, there are many other studies that have used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Reference of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Reference of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD271》 was written by Morita, Shinkichi; Mochizuki, Mai; Shibuya-Takahashi, Rie; Nakamura-Shima, Mao; Yamazaki, Tomoko; Imai, Takayuki; Asada, Yukinori; Matsuura, Kazuto; Kawamura, Sadafumi; Yamaguchi, Kazunori; Yasuda, Jun; Sugamura, Kazuo; Katori, Yukio; Satoh, Kennichi; Tamai, Keiichi. Category: ethers-buliding-blocks And the article was included in Monoclonal Antibodies in Immunodiagnosis and Immunotherapy in 2020. The article conveys some information:

CD271 is a common receptor for all neurotrophins that is localized to neurons, endothelial cells, and the basal layer of the epithelium in normal tissue. Recently, we and others reported that CD271 plays essential roles in the development of squamous cell carcinoma, especially in tumor-initiating cells. Since little is known about how CD271 regulates cancer cell initiation and proliferation, antibodies that recognize different domains of CD271 are needed to enable investigation. Therefore, this study aimed to develop an antihuman CD271 antibody by immunizing mice with a CD271 antigen produced by a baculovirus. The antibody was named hCD271mAb#13, and it recognized cysteine-rich domain 1 with a higher affinity than the com. available antibody ME20.4. We determined that hCD271mAb#13 is suitable for flow cytometry, Western blotting, immunocytochem., and immunohistochem. of formalin-fixed paraffin-embedded tissue. Use of hCD271mAb#13 for CD271 labeling could enable detailed analyses of cancer cell regulation and other biol. processes.6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Category: ethers-buliding-blocks) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 106685-40-9In 2020 ,《Vitamin A derivatives use in the treatment of skin conditions》 appeared in International Journal of Current Pharmaceutical Research. The author of the article were Al-Abadie, Mohammed; Oumeish, Faris; Al-Rubaye, Mohammed; Rafiq, Shahid; Ball, Patrick Anthony; Morrissey, Hana. The article conveys some information:

A review. This paper aims to develop prescribers’ knowledge about their benefits, to improve their usability and aids in alleviating patient concerns to improve therapeutic outcomes in dermatol. conditions. In acne vulgaris, adapalene gel and tretinoin cream showed equal efficacy. In psoriasis the combination of acitretin and PUVA was superior to PUVA alone. Acitretin showed a reduction of 41% in the Nail Psoriasis Severity Index and similar efficacy to potent steroids and calcipotriol. In chronic hand eczema, alitretinoin showed 50% improvement in patient’s refractory to steroid treatment. In photoaging and aging, retinoids were shown to increase the synthesis and decrease the degradation rate of collagen and hyaluronate, reducing the impact of aging. In rosacea, topical and systemic isotretinoin showed complete remission in 24% of the patients compared to only 14% with antibiotics (metronidazole and doxycycline). In lichen planus, isotretinoin demonstrated clin. and histopathol. efficacy. In cutaneous T-cell lymphoma, bexarotene used alone or with PUVA or narrow band UVB, showed a response between 80.0% to 84.0%. Lastly in Kaposi sarcoma alitretinoin gel showed superiority to all other agents and better tolerance. This review highlights the benefit of timely use of vitamin A derivatives to encourage wider use. In the part of experimental materials, we found many familiar compounds, such as 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Related Products of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Related Products of 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《A novel near-infrared fluorescent probe for detecting intracellular alkaline phosphatase and imaging of living cells》 were Xu, Longbin; He, Xu; Huang, Yibing; Ma, Pinyi; Jiang, Yanxiao; Liu, Xin; Tao, Shuo; Sun, Ying; Song, Daqian; Wang, Xinghua. And the article was published in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2019. Electric Literature of C8H8O3 The author mentioned the following in the article:

Development of novel near-IR (NIR) fluorescent probes for the monitoring of active substances in living organism is desirable in biol. studies. Herein, we designed a novel NIR MTR fluorophore which has a longer emission wavelength, greater Stokes shift and higher quantum yield than the classic hemicyanine NIR fluorophore. The synthesized MTR-derived NIR probe (MTR-P, I) is highly selective and sensitive to alk. phosphatase (ALP) activity. In the presence of ALP, MTR-P exhibited increased fluorescence signal by up to 56 fold at 723 nm, and it was determined to be 0.042 U L-1. In addition, the mechanism of the MTR-P probe was further examined by HPLC, mass spectrometry and DFT/TDDFT calculations The NIR probe MTR-P was successfully applied to measure the levels of alk. phosphatase in different types of cells by fluorescence imaging. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Electric Literature of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Electric Literature of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

COA of Formula: C8H8O3In 2020 ,《Experimental and theoretical investigation of ground state intramolecular proton transfer (GSIPT) in salicylideneaniline Schiff base derivatives in polar protic medium》 was published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The article was written by Das, Bijoya; Chakraborty, Amrita; Chakraborty, Shamik. The article contains the following contents:

Ground state intramol. proton transfer process has been comprehensively investigated in three salicylideneaniline Schiff base derivatives (SB1, SB2, and SB3) using exptl. and theor. methods. It has been confirmed that all the three Schiff base mols. in the ground electronic state exist in the enol form in non-polar and polar aprotic solvents. Keto form is being populated by the polar protic solvent through ground state intramol. proton transfer (GSIPT) process. Ground state equilibrium between the enol and keto tautomers for SB1 and SB3 is mainly governed by the proton donating ability of the solvent. Ground state equilibrium between the enol and keto tautomers of SB2 which is a positional isomer of SB3 is governed by the polarity and proton donating ability of the solvents. Excited state intramol. proton transfer (ESIPT) process is also evidenced in all the three Schiff base mols. Theor. calculations at the B3LYP/cc-pVDZ level in the gas phase and in different solvents using polarisable continuum model (PCM) have failed to establish the GSIPT process. Microsolvation of individual enol and keto conformers has been investigated considering upto three solvent mols. The energetics of the individual conformers together with the corresponding transition state have been calculated It has been confirmed that the keto conformer is more stable compared to the enol conformer in microsolvated cluster of three methanol mols. Lowering of activation energy for the enol to keto tautomerisation in the presence of methanol also supports the exptl. observation for GSIPT process. TDDFT/B3LYP/cc-pVDZ single point calculations for microsolvated clusters of enol and keto form of the Schiff base mols. exhibit an excellent agreement with the exptl. obtained absorption spectra. Difference in spectral nature of the Schiff base mols. has been explained using natural bond orbital (NBO) anal. Quantum theory of atoms in mols. (QTAIM) has also been utilized to understand the GSIPT process in detail. The results came from multiple reactions, including the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3COA of Formula: C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.COA of Formula: C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Subclinical effects of adapalene-benzoyl peroxide: a prospective in vivo imaging study on acne micromorphology and transfollicular delivery》 was written by Fuchs, C. S. K.; Ortner, V. K.; Hansen, F. S.; Philipsen, P. A.; Haedersdal, M.. Formula: C28H28O3 And the article was included in Journal of the European Academy of Dermatology and Venereology in 2021. The article conveys some information:

Adapalene-benzoyl peroxide (A-BPO) is a first-line topical treatment for acne vulgaris. In vivo reflectance confocal microscopy (RCM) and optical coherence tomog. (OCT) detect micromorphol. changes over time and visualize transfollicular delivery. To visualize temporal, subclin. effects of A-BPO on acne micromorphol. using RCM and OCT, and evaluate their impact on transfollicular delivery of microparticulate carrier systems. Fifteen patients with mild to moderate acne received a 6-wk course of A-BPO. Micromorphol. changes were evaluated at time 0, 3 and 6 wk with RCM (n = 1190 images) and OCT (n = 210 scans). Transfollicular delivery of microparticles was assessed at baseline and week 6. In vivo imaging visualized steady normalization of skin micromorphol. in response to A-BPO over 6 wk, including decreased hyperkeratinization of follicular borders (RCM median decrease -71.2%, P < 0.05), reduced intrafollicular keratinous content (RCM median decrease -47.7%, P < 0.05) and increased epidermal thickness (OCT median increase of 25.25%, P < 0.05). Imaging visualized microparticles in the follicular unit. Despite a visible reduction in keratin and sebum, transfollicular microparticle delivery appeared unaffected. Reflectance confocal microscopy and OCT detect A-BPO-induced changes in micromorphol. and visualize transfollicular microparticle delivery. Keratolysis and sebolysis did not have a measurable effect on transfollicular delivery of microparticles. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Formula: C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Formula: C28H28O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem