Month: October 2022

The author of 《Multi-drug hybrid delivery systems with distinct release profiles based on gelatin/collagen containing vesicles derived from block copolymers》 were Brey Gil, Viviane S.; Brey Gil, Camila S.; Goulart, Gisele Assis Castro; Orefice, Rodrigo L.. And the article was published in International Journal of Biological Macromolecules in 2019. Synthetic Route of C28H28O3 The author mentioned the following in the article:

Hybrid delivery systems can release multiple drugs with different profiles and have several applications, including skin dressing. In this work, the co-solvent technique was used for the preparation of nanometric vesicles based on poly(styrene-b-ethylene oxide) block copolymer (BCPVs) containing adapalene (AD). The BCPVs were incorporated into collagen and gelatin matrixes together with free AD and silver sulfadiazine (SSD). The AD content of BCPVs and their release capacity were analyzed by using UV-visible spectroscopy (UV-Vis). The gelatin and collagen matrixes were evaluated for their ability to release AD and SSD through an in vitro release study. The obtained results confirmed that the production of empty and AD-loaded BCPVs was viable. The degree of AD encapsulation in BCPVs was 9.0% and the in vitro test revealed a constant, slow, and prolonged release of AD content from AD-loaded BCPVs. The combination of free and encapsulated multiple drugs in hybrid delivery systems based on gelatin and collagen matrixes was shown to act as a skin dressing that combined the progressive release of large amounts of drugs within the first hours of use (to restrict infection) with a more prolonged and slow release of AD to enhance skin healing. The experimental process involved the reaction of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Synthetic Route of C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Synthetic Route of C28H28O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Comments on chemical properties reported for diphenyl disulfide and its derivatives: The merit of the phenyl groups》 was published in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2020. These research results belong to Lin, Hung-Sung; Wu, Yan; Liu, Yu-Ju; Chen, Shu-Hui; Chen, Wei-Ting; Wang, Shao-Pin. SDS of cas: 882-33-7 The article mentions the following:

The sym. 2,2′-disubstitued derivatives of di-Ph disulfide showing widely spanning rates of electrophilic attack of the HIV-1 nucleocapsid protein p7 zinc fingers have been rationalized, based on the LUMO (LUMO)-lowering approach, by the substituents′ π-effects and the hydrogen bond stabilization effects. In the 2,2′-amide- and 4,4′-N-amide-substituted derivatives, the extent of LUMO lowering has been reduced by the destabilization of lone-pair bond orbital, lp(N), present on the nitrogen atom of N-amide. From the natural bond orbital viewpoint, hydrogen bond stabilization of LUMO is mainly governed by stabilization of the σ*SS bond orbital. The experimental process involved the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7SDS of cas: 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.SDS of cas: 882-33-7Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of coumarin derivatives in a microfluidic flow system employing the Pechmann condensation: A case study》 was written by Liu, Ling-Kang; Deng, Jhao-Hong; Guo, Yang-Ming. COA of Formula: C7H8O2 And the article was included in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2020. The article conveys some information:

For the synthesis of coumarin derivatives using the Pechmann condensation scheme, an acidic ionic liquid catalyst, abbreviated as [EBsImH][HSO4], was prepared from the ring opening of 1,4-butanesultone by 1-ethylimidazole, followed by the addition of 1 equivalent H2SO4(c). The [EBsImH][HSO4]-catalyzed Pechmann condensation reactions proceeded smoothly in a batch setup, with recyclable [EBsImH][HSO4] showing great catalytic activity. The acidic ionic liquid catalyst [EBsImH][HSO4] was recovered from EtOAc/H2O extraction of the product mixture, where the H2O layer was worked up and dried for reuse in consecutive runs of the Pechmann condensation reactions, maintaining >85% conversion for four times. The catalytic reactions were also carried out in a microfluidic flow setup. The flow parameters, the reactant molar amounts, and the addnl. H2SO4 as a modifying acid catalyst were optimized in the current case study. A min. conversion rate of 2.8 g/h of coumarin derivatives was demonstrated. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6COA of Formula: C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneCOA of Formula: C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bhuyar, Prakash; Rahim, Mohd hasbi ab.; Maniam, Gaanty pragas; Govindan, Natanamurugaraj published their research in Journal of Microbiology, Biotechnology and Food Sciences in 2021. The article was titled 《Isolation and characterization of bioactive compounds in medicinal plant Centella asiatica and study the effects on fungal activities》.Computed Properties of C10H20O5 The article contains the following contents:

Medicinal plants are sources of important therapeutic aids for alleviating human ailments. The present research investigation was carried out to study anti-fungal activity of C. asiatica were tested against C. albicans, Aspergillus niger, and Penicillium sp. using two methods, disk diffusion method and broth dilution method. C. asiatica crude methanol extract was found to be the most effective against fungal activity. Compared to disk diffusion, broth dilution was a more appropriate method to quant. determine the anti-Candida activity of plant extract, whereby the MIC values of the crude extracts was determined The result from disk diffusion assay demonstrates that plant extracts have an inhibitory effect. However, the broth dilution method result reveal that C. asiatica crude methanol extract has lower MIC values, meaning it has more prove that C. asiatica has an anti-fungal effect. Bioactive anal. results reveled that bioactive compounds present in the leaf, stems, roots, and the whole plant extract from Centella asiatica are the major chem. constituents are n-Hexadecanoic acid (99%), cis-Vaccenic acid (91%), 5-Hydroxymethylfurfural (88%), Tetradecanoic acid (86%). Further study is required to find out the specific phytochem. which is responsible for its medicinal value. In the part of experimental materials, we found many familiar compounds, such as 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Computed Properties of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Computed Properties of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Abdollahi, Maryam F.; You, Jian; Wang, Tao; Zhao, Yuming published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Molecular tuning of the crystallization-induced emission enhancement of diphenyl-dibenzofulvene luminogens》.HPLC of Formula: 10365-98-7 The article contains the following contents:

The absorption and emission properties of various diphenyl-dibenzofulvene (DP-DBF) derivatives were investigated, and their crystallization-induced emission enhancement (CIEE) performances were found to show a clear correlation with the twist angle around the C=C bond of the DP-DBF structure. The experimental process involved the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7HPLC of Formula: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.HPLC of Formula: 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ndima, Lubabalo; Hosten, Eric C.; Betz, Richard published an article in 2021. The article was titled 《Crystal structure of 2-hydroxy-4-methoxy benzaldehyde, C8H8O3》, and you may find the article in Zeitschrift fuer Kristallographie – New Crystal Structures.Recommanded Product: 673-22-3 The information in the text is summarized as follows:

C8H8O3, monoclinic, P21/c (number 14), a = 6.3037(3) Å, b = 33.102(2) Å, c = 7.0471(4) Å, β = 102.105(3)°, V = 1437.79(14) Å3, Z = 8, R gt(F) = 0.0433, wR ref(F 2) = 0.1087, T = 200 K. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhao, Baohai; Lin, Jimao; Zhao, Cuihua; Wang, Ziying published an article in Acta Crystallographica, Section E: Structure Reports Online. The title of the article was 《1,4-Dimethoxy-2,5-bis{2-[4-(trifluoromethyl)phenyl]ethynyl}benzene》.Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzene The author mentioned the following in the article:

The asym. unit of the title compound, C26H16F6O2, contains one half of the mol. situated on an inversion center. In the rod-like mol., the two terminal benzene rings form a dihedral angle of 71.9 (1)° with the central benzene ring. The trifluoromethyl group is rotationally disordered over two orientations in a 0.53 (1):0.47 (1) ratio. The crystal packing exhibits no classical intermol. interactions. The results came from multiple reactions, including the reaction of 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzene)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzeneAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2017,Tang, Tommy Siu-Ming; Liu, Hua-Wei; Lo, Kenneth Kam-Wing published 《Monochromophoric iridium(III) pyridyl-tetrazine complexes as a unique design strategy for bioorthogonal probes with luminogenic behavior》.Chemical Communications (Cambridge, United Kingdom) published the findings.Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

The coordination of pyridyl-tetrazine to a cationic iridium(III) center affords a novel class of luminogenic bioorthogonal probes for biomol. labeling and cellular imaging. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A novel near-infrared turn-on fluorescent probe for the detection of Fe3+ and Al3+ and its applications in living cells imaging》 was written by Li, Bai; Mei, Huihui; Chang, Yongxin; Xu, Kuoxi; Yang, Li. Computed Properties of C8H8O3 And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020. The article conveys some information:

A new hemicyanidine-based colorimetric-fluorescent probe L (I) has been synthesized and characterized by x-ray single crystal diffraction, NMR, HRMS and other technologies. The probe L serves as a “”turn-on”” probe for the detection of Fe3+ and Al3+ ions in DMF-HEPES system with a high sensitivity and an excellent selectivity. The probe L manifesting the color of the solution containing L turns red on the addition of Fe3+, and turns pink on the addition of Al3+. The fluorescence turn-on detection of Fe3+ and Al3+ ions is attributed to the photo-induced electron transfer (PET) process and the exertion of the chelation-enhanced fluorescence effect (CHEF) mechanism. The results of thin layer silica gel plate coloration experiments also present the same characteristics. Addnl., further the probe L exhibit good cell permeability and could be employed to monitor Fe3+ and Al3+ ions in the living cells. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Computed Properties of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Computed Properties of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《An investigation on the effect of drug physicochemical properties on the enhancement strength of enhancer: The role of drug-skin-enhancer interactions》 was written by Xu, Wenwen; Liu, Chao; Zhang, Yang; Quan, Peng; Yang, Degong; Fang, Liang. Application of 106685-40-9This research focused ontransdermal drug physicochem enhancement strength permeation enhancer solubility POCC; Chemical permeation enhancers; Permeation-enhancing mechanism; Physicochemical parameter of drugs; Polar surface area; Polarizability. The article conveys some information:

The aim of present work was to investigate the influence of drug physicochem. properties on the enhancement effect of enhancers, which guided the application of enhancers in different drug transdermal prescriptions. Firstly, Polyglyceryl-3 dioleate (POCC) was selected as a model enhancer and its enhancement effect on ten drugs was assessed by in vitro skin permeation experiment Secondly, the correlation anal. of physicochem. properties of drugs was carried out from the aspects of partition and permeation. The interactions of drug-skin-POCC were elucidated by FT-IR, mol. docking, solubility parameters calculation, ATR-FTIR, Raman study, mol. dynamics simulation and confocal laser scanning microscopy (CLSM). The results showed that the enhancement ratio (ER) of drugs was ranging from 2.23 to 7.45. On one hand, the miscibility between drugs with low polar surface area (P.S.A) and donor solution was decreased more pronounced by the addition of POCC because of the drug was difficult to form hydrogen-bond with POCC, facilitating the vehicle/SC partition of drugs. On the other hand, the permeation of drugs with low P. S. A and polarizability was enhanced more significantly by POCC because the drug was less likely to interact with skin lipids compared to others, causing that POCC had more chance to interact with skin lipids to improve permeation drugs across the SC more easily. In conclusion, the different strength of drug-skin-POCC interactions was the main reason for the discrepancy in the enhancement effect of the POCC on ten drugs, which laid a basis for the research on the drug-specific mol. mechanisms of enhancers. In the experiment, the researchers used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application of 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem