Month: October 2022

In 2019,Journal of Polymer Science, Part A: Polymer Chemistry included an article by Yamauchi, Akira; Sudo, Atsushi; Endo, Takeshi. COA of Formula: C5H13NO2. The article was titled 《Polymer with Zwitterionic Structure in Main Chain via Polyaddition of Bifunctional Cyclic Amidine and Diisothiocyanate》. The information in the text is summarized as follows:

Another mode of application for the addition reaction of cyclic amidine and isothiocyanate to the construction of polymers with zwitterionic moieties, i.e., polyaddition of a bifunctional cyclic amidine monomer and diisothiocyanate. The thermal properties and ionic conductivity of the resulting polymer were investigated. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5COA of Formula: C5H13NO2) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.COA of Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Evaluation of phytochemical compounds and antimicrobial activities of Hemidesmus indicus》 were Ashalatha, K. S.; Raja, Shantha Reddy A.; Raveesha, H. R.. And the article was published in Asian Journal of Pharmaceutical and Clinical Research in 2019. Category: ethers-buliding-blocks The author mentioned the following in the article:

The present study was aimed to investigate the phytochem. screening, antibacterial activities, and identification of bioactive compounds by gas chromatog.-mass spectrometry (GC-MS) and high-performance liquid chromatog. (HPLC) in Hemidesmus indicus root extracts The qual. and quant. phytochem. anal. was carried out using standard methods. Bioactive compounds were identified by GC-MS and HPLC anal. Antibacterial activity of different solvent extracts was carried out using the agar well diffusion method. Preliminary phytochem. anal. showed the presence of phenols, tannins, alkaloids, flavonoids, proteins, reducing sugar, glycosides, amino acids, steroids, terpenoids, resins, volatile oil, emodols, and coumarins. Total phenolic and flavonoid contents were higher in the methanolic extracts compared to other solvent extracts 2-hydroxy 4-methoxy benzaldehyde was identified as the major compound The maximum zone of inhibition was observed in the methanolic extracts of root against Klebsiella pneumoniae, Staphylococcus aureus, and Escherichia coli. Our results suggest that H. indicus plant contains many chem. compounds and its root exhibits the wide range of antimicrobial activity. Further studies have to be carried out regarding the in vitro multiplication of plant and to enhance the root flavoring compounds for medicinal, food, and beverage industries. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Category: ethers-buliding-blocks

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Ether – Wikipedia,
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Synthetic Route of C9H19NO4In 2016 ,《Protein-Coupled Fluorescent Probe To Visualize Potassium Ion Transition on Cellular Membranes》 appeared in Analytical Chemistry (Washington, DC, United States). The author of the article were Hirata, Tomoya; Terai, Takuya; Yamamura, Hisao; Shimonishi, Manabu; Komatsu, Toru; Hanaoka, Kenjiro; Ueno, Tasuku; Imaizumi, Yuji; Nagano, Tetsuo; Urano, Yasuteru. The article conveys some information:

K+ is the most abundant metal ion in cells, and changes of [K+] around cell membranes play important roles in physiol. events. However, there is no practical method to selectively visualize [K+] at the surface of cells. To address this issue, we have developed a protein-coupled fluorescent probe for K+, TLSHalo. TLSHalo is responsive to [K+] in the physiol. range, with good selectivity over Na+ and retains its K+-sensing properties after covalent conjugation with HaloTag protein. By using cells expressing HaloTag on the plasma membrane, we successfully directed TLSHalo specifically to the outer surface of target cells. This enabled us to visualize localized extracellular [K+] change with TLSHalo under a fluorescence microscope in real time. To confirm the exptl. value of this system, we used TLSHalo to monitor extracellular [K+] change induced by K+ ionophores or by activation of a native Ca2+-dependent K+ channel (BK channel). Further, we show that K+ efflux via BK channel induced by elec. stimulation at the bottom surface of the cells can be visualized with TLSHalo by means of total internal reflection fluorescence microscope (TIRFM) imaging. Our methodol. should be useful to analyze physiol. K+ dynamics with high spatiotemporal resolution In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Synthetic Route of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Synthetic Route of C9H19NO4 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

HPLC of Formula: 106685-40-9In 2020 ,《Solid lipid microparticles for hair follicle targeting of adapalene and benzoyl peroxide – Release through targeted erosion》 was published in Journal of Drug Delivery Science and Technology. The article was written by Brammann, Christoph; Bornemann, Christel; Kannewurf, Ramon; Mueller-Goymann, Christel C.. The article contains the following contents:

Sebum-dependent targeting of the upper hair follicle by solid lipid microparticles has been demonstrated for retinoids using adapalene as an example. An extension of this formulation principle to the combination of adapalene/benzoyl peroxide was achieved on the basis of congealed solid-in-oil dispersions of nanoparticulate benzoyl peroxide, which were incorporated into the solid lipid microparticles. To investigate the dermal distribution and release behavior of the solid lipid microparticles after application, fluorescence microscopic ex vivo studies on porcine ear skin samples treated with the exptl. vehicle were supplemented by calorimetric skin lipid interaction studies and release experiments on lipid-coated membranes, investigating the influence of sebum and stratum corneum lipids on the solid lipid microparticle matrix. Fluorescent microscopic images of the treated skin confirm the observation of preferential deposition in the upper hair follicle. In addition, the release experiments show a sebum-dependent release of the active ingredients, with no detectable release in the presence of stratum corneum lipids. The observed discrepancy is probably a result of the rapid disintegration of the particles on contact with sebum, as calorimetric investigations suggest. This behavior, which is based on the similarity between the sebum components and the lipid matrix, allows a targeted release into sebum and thus increased follicular penetration. In addition to this study using 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid, there are many other studies that have used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9HPLC of Formula: 106685-40-9) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.HPLC of Formula: 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Alnaja, Alaa M. A.; Farghaly, Thoraya A.; El-zahabi, Heba S. A.; Shaaban, Mohamed R. published an article in 2021. The article was titled 《Cytotoxicity, Docking Study of New Fluorinated Fused Pyrimidine Scaffold: Thermal and Microwave Irradiation Synthesis》, and you may find the article in Medicinal Chemistry (Sharjah, United Arab Emirates).Synthetic Route of C5H13NO2 The information in the text is summarized as follows:

Azolopyrimidines are imposed on the arena of drugs treated for cancer. The urgent need to discover new selective anticancer agents, paved the way to explore the antitumor significance of such fused systems. From the synthetic point of view, Microwave facilitated technique for synthesis is very strongly associated with green method in chem. field. Our aim is to synthesize bioactive compounds using docking simulation run by MOE program to explore the binding mode of the most active enzyme inhibitor among the target compounds In addition to the use of conventional heating, the MARS system of CEM utilized for Microwave irradiation that is equipped with a multi-mode platform with a magnetic stirring plate and a rotor that allows the parallel processing of many vessels per batch. All the synthesized compounds were tested for their anticancer activity against hepatic cancer (HepG-2), breast cancer (MCF-7) and colon cancer (HCT-116). Screening against the cancer cell lines was performed, using doxorubicin as a reference drug. Docking studies were conducted using MOE software. A novel series of fluorinated fused-pyrimidine namely, pyrazolopyrimidine, triazolopyrimidine and pyrimidobenzimidazole were designed and synthesized conventionally and under microwave irradiations. The mechanistic pathways as well as the structure of all products were debated and demonstrated based on all possible spectral data. In-vitro examination of the novel prepared derivatives vs. the three different human cancer cell lines [hepatic cancer (HepG-2), breast cancer (MCF-7) and colon cancer (HCT-116)] was evaluated to estimate their actual activity. We have developed a simple, facile, and efficient procedure for the formation of new series of azolopyrimidines. All spectra of all products were investigated deliberately to confirm their structures. The anti-cancer activity has been examined against three cancer cell lines e.g. HepG-2, MCF-7 and HCT116. Mol. modeling study was carried out in order to rationalize the in vitro anti-tumor results. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Synthetic Route of C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gharpure, Santosh J.; Jegadeesan, S.; Vishwakarma, Dharmendra S. published an article in 2021. The article was titled 《Acid-catalysed iterative generation of o-quinone methides for the synthesis of dioxabicyclo[3.3.1]nonanes: total synthesis of myristicyclins A-B》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Recommanded Product: 673-22-3 The information in the text is summarized as follows:

A practical and efficient method for the synthesis of bioactive flavanoids relying on the strategic use of o-quinine methide (o-QM) intermediates was reported. This involved Bronsted acid-catalyzed iterative generation of o-QMs/[4+2] cycloaddition/intermol. Michael addition/cyclative acetalization in a cascade sequence for the synthesis of dioxabicyclo[3.3.1]nonanes I [R1 = H, 7-OMe, 8-OMe; R2 = H, CO2Me, CO2Et; R3 = H, Me, Ph, etc.]. The ‘one-pot’, controlled cascade sequence successfully provided the shortest route amenable for gram scale synthesis of natural products (±)-myristicyclins A-B II and III. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Development of a method to measure laccase activity on methoxyphenolic food ingredients and isomers》 was written by Manzano-Nicolas, Jesus; Marin-Iniesta, Fulgencio; Taboada-Rodriguez, Amaury; Garcia-Canovas, Francisco; Tudela-Serrano, Jose; Munoz-Munoz, Jose Luis. Product Details of 150-19-6 And the article was included in International Journal of Biological Macromolecules in 2020. The article conveys some information:

We studied the laccase-catalyzed oxygenation of methoxyphenolic food ingredients, such as 2-methoxyphenol (guaiacol) and 2,6-dimethoxyphenol (syringol), isomers such as 3- and 4-methoxyphenol, and 2,3-, 3,4- and 3,5-dimethoxyphenol. These methoxyphenolic substrates generate unstable free radicals, which leads to the erroneous determination of steady state rates. The addition of small quantities of ascorbic acid as coupling reagent generates a lag period because it reduces free radicals to methoxyphenols. Measurement of the length of the lag period provides the reliable determination of true steady state rates. We describe the application of this chronometric method to the kinetic characterization of the oxidation of the above methoxyphenolic substrates by Trametes versicolor laccase. The experimental part of the paper was very detailed, including the reaction process of m-Methoxyphenol(cas: 150-19-6Product Details of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneProduct Details of 150-19-6

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Ether – Wikipedia,
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Maritz, Marius; Hosten, Eric C.; Betz, Richard published an article in 2021. The article was titled 《Crystal structure of ortho-methoxy benzaldehyde, C8H8O2 – a second polymorph and deposition of 3D coordinates》, and you may find the article in Zeitschrift fuer Kristallographie – New Crystal Structures.Application In Synthesis of 2-Methoxybenzaldehyde The information in the text is summarized as follows:

C8H8O2, tetragonal, P43212 (number 96), a = 10.9521(5) Å, c = 23.3014(17) Å, V = 2795.0(3) Å3, Z = 16, R gt(F) = 0.0317, wR ref(F 2) = 0.0883, T = 200 K. The experimental process involved the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Application In Synthesis of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Application In Synthesis of 2-Methoxybenzaldehyde

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Ether – Wikipedia,
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《A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe》 was written by Albertoni, Barbara; Hannam, Jeffrey S.; Ackermann, Damian; Schmitz, Anton; Famulok, Michael. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateThis research focused ontrifluoromethylphenyl diazirine SecinH3 photoaffinity probe cytohesin. The article conveys some information:

The synthesis of a trifluoromethylphenyl diazirine photoaffinity probe of the cytohesin inhibitor SecinH3 is described. The probe exhibits improved labeling efficiency over a benzophenone-based probe and thus is more suitable for photoaffinity labeling in complex biol. samples. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C10H10O5On November 30, 1982 ,《Acid-labile resin linkage agents for use in solid phase peptide synthesis》 appeared in International Journal of Peptide & Protein Research. The author of the article were Sheppard, Robert C.; Williams, Brian J.. The article conveys some information:

Acid-labile peptide-resin linkage agents I (R = H, OMe) were prepared from 4-formylphenol (II) and 3-methoxyphenol (III), resp. Thus, III was formylated with POCl3/DMF to give benzaldehyde IV (R1 = H), which was treated with ClCH2CO2H in the presence of aqueous NaOH to give IV (R1 = CH2CO2H), which was reduced by NaBH4 to give I (R = OMe). II was treated with ClCH2CO2H to give 4-HCOC6H4OCH2CO2H, which was reduced by NaBH4 to give I (R = H). I (R = OMe) is suitable for the preparation of peptide fragments having tert-Bu-based side-chain protective groups. In addition to this study using 2-(4-Formyl-3-methoxyphenoxy)acetic acid, there are many other studies that have used 2-(4-Formyl-3-methoxyphenoxy)acetic acid(cas: 84969-24-4Formula: C10H10O5) was used in this study.

2-(4-Formyl-3-methoxyphenoxy)acetic acid(cas: 84969-24-4) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C10H10O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem