Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Recommanded Product: 2-Methoxy-N-methylethanamine.
Torrie, Leah S.;Robinson, David A.;Thomas, Michael G.;Hobrath, Judith V.;Shepherd, Sharon M.;Post, John M.;Ko, Eun-Jung;Ferreira, Rafael Alves;Mackenzie, Claire J.;Wrobel, Karolina;Edwards, Darren P.;Gilbert, Ian H.;Gray, David W.;Fairlamb, Alan H.;De Rycker, Manu research published 《 Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase》, the research content is summarized as follows. Methionyl-tRNA synthetase (MetRS) is a chem. validated drug target in kinetoplastid parasites Trypanosoma brucei and Leishmania donovani. To date, all kinetoplastid MetRS inhibitors described bind in a similar way to an expanded methionine pocket and an adjacent, auxiliary pocket. In the current study, we have identified a structurally novel class of inhibitors containing a 4,6-diamino-substituted pyrazolopyrimidine core (the MetRS02 series). Crystallog. studies revealed that MetRS02 compounds bind to an allosteric pocket in L. major MetRS not previously described, and enzymic studies demonstrated a noncompetitive mode of inhibition. Homol. modeling of the Trypanosoma cruzi MetRS enzyme revealed key differences in the allosteric pocket between the T. cruzi and Leishmania enzymes. These provide a likely explanation for the lower MetRS02 potencies that we observed for the T. cruzi enzyme compared to the Leishmania enzyme. The identification of a new series of MetRS inhibitors and the discovery of a new binding site in kinetoplastid MetRS enzymes provide a novel strategy in the search for new therapeutics for kinetoplastid diseases.
38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Recommanded Product: 2-Methoxy-N-methylethanamine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem