Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. COA of Formula: C8H11BO4.
Son, Seung Hwan;Do, Ji Min;Yoo, Ji-Na;Lee, Hyun Woo;Kim, Nam Kwon;Yoo, Hyung-Seok;Gee, Min Sung;Kim, Jong-Ho;Seong, Ji Hye;Inn, Kyung-Soo;Seo, Min-Duk;Lee, Jong Kil;Kim, Nam-Jung research published 《 Identification of ortho catechol-containing isoflavone as a privileged scaffold that directly prevents the aggregation of both amyloid β plaques and tau-mediated neurofibrillary tangles and its in vivo evaluation》, the research content is summarized as follows. In this study, polyhydroxyisoflavones that directly prevent the aggregation of both amyloid β (Aβ) and tau were expediently synthesized via divergent Pd(0)-catalyzed Suzuki-Miyaura coupling and then biol. evaluated. By preliminary structure-activity relationship studies using thioflavin T (ThT) assays, an ortho-catechol containing isoflavone scaffold was proven to be crucial for preventing both Aβ aggregation and tau-mediated neurofibrillary tangle formation. Addnl. TEM experiment confirmed that ortho-catechol containing isoflavone 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one significantly prevented the aggregation of both Aβ and tau. To investigate the mode of action (MOA) of 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, which possesses an ortho-catechol moiety, 1H-15N HSQC NMR anal. was thoroughly performed and the result indicated that 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one could directly inhibit both the formation of Aβ42 fibrils and the formation of tau-derived neurofibrils, probably through the catechol-mediated nucleation of tau. Finally, 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one was demonstrated to alleviate cognitive impairment and pathologies related to Alzheimers disease in a 5XFAD transgenic mouse model.
122775-35-3, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., COA of Formula: C8H11BO4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem