Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Reference of 111-90-0.
Sinico, Chiara;Fadda, Anna Maria;Valenti, Donatella;Pireddu, Rosa;Corrias, Francesco;Schlich, Michele;Pitzanti, Giulia;Lai, Francesco research published 《 Nanoliposomes@Transcutol for in vitro skin delivery of 8-methoxypsoralen》, the research content is summarized as follows. The 8-methoxypsoralen is the most common drug in psoralen plus UV light irradiation therapy for the treatment of severe psoriasis. Despite of the efficacy, its classic oral administration leads to several serious adverse effects. However, the topical psoralen application produces a drug skin accumulation lower than that obtained by oral administration, due to the drug low skin permeability. In this paper, 8-methoxypsoralen loaded Penetration Enhancer-contg Vesicles were prepared using soy phosphatidylcholine and the penetration enhancer Transcutol (5% or 10%) and characterized in terms of size, polydispersity index, zeta potential and encapsulation efficiency. No statistically significant differences in both size (∼135 nm) and encapsulation efficiency (∼65%) were found for different Transcutol concentration Transdermal delivery study assessed by Franz diffusion cells, showed that the 8-methoxypsoralen mainly accumulated into the stratum corneum. Moreover, after Penetration Enhancer-contg Vesicles application, the drug recovered in this layer is almost double of that delivered by conventional liposomes, while no significant difference was found from the different Transcutol concentrations Finally, biocompatibility checked by an MTT assay, demonstrated that the incubation of human keratinocytes for 24 h with 8-methoxypsoralen loaded Penetration Enhancer-contg Vesicles did not significantly reduce cell viability.
111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Reference of 111-90-0
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem