Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. SDS of cas: 111-90-0.
Singha, L. Ronibala;Das, Malay K. research published 《 Effect of Mesua ferrea Linn. seed kernel oil on percutaneous absorption of Diltiazem hydrochloride through pig ear epidermis: A mechanistic study》, the research content is summarized as follows. The present study reports the mechanistic investigation on Mesua ferrea L. seed kernel oil as a natural skin permeation enhancer. The natural oil was extracted by Soxhlation method. The permeation parameters resulting from the ex vivo skin permeation study of the model drug Diltiazem HCl across oil pre-treated pig ear epidermis revealed better transdermal flux of the test groups compared to the control one. Also, the investigated oil exhibited significantly higher penetration enhancement effect compared to the standard penetration enhancer Transcutol and the maximum permeation enhancement effect was observed at 15% volume/volume in PG. The permeation enhancement mechanistic studies by FT-IR, DSC and SEM suggested that the enhancement effect of the oil was due to the fluidization of lipids and interaction with keratinocytes of the stratum corneum maintaining morphol. integrity of the skin membrane. Furthermore, the test oil was found to be non-irritant in nature and safe for topical application. These findings suggests the Mesua ferrea L. seed oil is an efficient and safe natural skin permeation enhancer providing the scope for future research on its usage in the development of transdermal drug delivery devices.
SDS of cas: 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem