Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Related Products of 111-90-0.
Shettar, Abhishek;Shankar, Vijay Kumar;Ajjarapu, Srinivas;Kulkarni, Vijay I.;Repka, Micheal A.;Murthy, S. Narasimha research published 《 Development and characterization of Novel topical oil/PEG creams of voriconazole for the treatment of fungal infections》, the research content is summarized as follows. Voriconazole (VRC), a second generation triazole derivative emerged as a promising candidate for the treatment of fungal infections. Voriconazole is com. available as oral and i.v. formulations, however administration through these routes is associated with several side effects like hepatotoxicity, photopsia and abdominal pain. Hence, percutaneous delivery of voriconazole through creams or hydrogels would be beneficial for preventing side effects due to other routes of administration. Voriconazole may potentially undergo degradation in formulations containing water. The objective of the study was to prepare a stable biphasic semisolid formulation using oil and PEG. The melt extrusion process was used as a continuous manufacturing technique for preparation of oil/PEG cream. Formulation composition and processing conditions were optimized based on the compatibility and pre-formulation studies. The developed creams were characterized for content uniformity, viscosity and in vitro drug release. The effect of Transcutol P and camphor: menthol (1:1) on the permeation of voriconazole was evaluated by ex vivo permeation studies. The voriconazole in oil/PEG formulation (93.44 ± 1.59%) were stable for 3 mo compared to control voriconazole hydrogel formulation (10.67 ± 0.03%) at 25°C (60% RH). The formulation with Transcutol P used as a permeation enhancer increased voriconazole permeation 9 folds compared to formulation without permeation enhancer. In conclusion, a stable oil/PEG voriconazole cream was successfully developed using continuous manufacturing process and can be used as alternate for i.v./oral voriconazole for treatment of fungal skin infections.
Related Products of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem