Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Recommanded Product: 2-Methoxy-N-methylethanamine.
Shao, Min;Chen, Xiaojuan;Yang, Fang;Song, Xiaojuan;Zhou, Yang;Lin, Qianmeng;Fu, Ying;Ortega, Raquel;Lin, Xiaojing;Tu, Zhengchao;Patterson, Adam V.;Smaill, Jeff B.;Chen, Yongheng;Lu, Xiaoyun research published 《 Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4》, the research content is summarized as follows. A series of aminoindazole derivatives I [R1 = 1-(2,6-dichloro-3-fluoro-phenyl)ethyl, 1-(2,6-dichlorophenyl)ethyl, (1R)-1-(3,5-dichloro-4-pyridyl)ethyl, (3,5-dichloro-4-pyridyl)methyl, 1-(3,5-dichloro-4-pyridyl)propyl; R2 = H, Me, Cl, etc.; R3 = H, MeO; R4 = H, 4-methylpiperazin-1-yl, morpholino, etc.] was designed and synthesized as new irreversible inhibitors of wild-type and gatekeeper mutant FGFR4. One representative compound I [R1 = (1R)-1-(3,5-dichloro-4-pyridyl)ethyl, R2 = F, R3 = H, R4 = 4-morpholino-1-piperidyl] exhibited excellent potency against FGFR4, FGFR4V550L and FGFR4V550M with nanomolar activity in both the biochem. and cellular assays while sparing FGFR1/2/3. While compound I [R1 = (1R)-1-(3,5-dichloro-4-pyridyl)ethyl, R2 = F, R3 = H, R4 = 4-morpholino-1-piperidyl] demonstrated modest in vivo antitumor efficacy in nude mice bearing the Huh-7 xenograft model consistent with its unfavorable pharmacokinetic properties, it provided a promising new starting point for future drug discovery combating FGFR4 gatekeeper mediated resistance in HCC patients.
Recommanded Product: 2-Methoxy-N-methylethanamine, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem