Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 530-59-6, formula is C11H12O5, Name is 3,5-Dimethoxy-4-hydroxycinnamic acid. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Application of C11H12O5.
Sawicki, Tomasz;Ruszkowska, Monika;Shin, Jessica;Starowicz, Malgorzata research published 《 Free and conjugated phenolic compounds profile and antioxidant activities of honeybee products of polish origin》, the research content is summarized as follows. In this study, the profile of free and conjugated phenolic compounds and antioxidant activity of bee bread, bee pollen, honey and beeswax samples from the same beehive was analyzed. The contents of free phenolic compounds and those released from the esters and glycosides bounds were analyzed by HPLC-TOF-MS/MS method. In the obtained extracts, the total of phenolic (TP) and flavonoid (TF) contents was measured using spectrophotometric methods, while antioxidant activity was determined by DPPH and ABTS in vitro assays. Therefore, in the tested honeybee products 23 phenolic compounds were identified, constituting of 14 phenolic acids and nine flavonoids. Among the phenolic acids, ferulic (bee bread), protocatechuic (bee pollen) and m-coumaric acids (honey and beeswax) were predominant. In case of flavonoids, the major compounds were vitexin in bee bread, orientin in bee pollen, and apigenin in honey. The highest TP and TF contents were detected in the bee pollen, and was 4.11 mg GAE/g and 0.41 mg Q/g, resp. Moreover, these compounds were mostly present in bound form. Honeybee product extracts had high scavenging ability against radicals, and their antioxidant activity differed significantly across samples (p < 0.05). Overall, this study demonstrates that selected honeybee products are an abundant source of the bioactive compounds with the characteristic profile of phenolic compound as well as antioxidant activity.
530-59-6, Sinapinic acid is a chemical compound that is the dihydroxybenzoic acid derivative of sinapic acid. It has been shown to have anti-inflammatory properties in vitro and in vivo. Sinapinic acid inhibits the activity of various enzymes, such as cyclooxygenase (COX), lipoxygenase (LOX), and 5-lipoxygenase-activating protein (FLAP). It also decreases levels of adhesion molecules and downregulates inflammatory response genes. Sinapinic acid has been shown to reduce inflammation by inhibiting the formation of proinflammatory mediators, such as prostaglandin E2 or leukotriene B4, in endothelial cells and mammary epithelial cells.
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively. Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline. Sinapic acid is also commonly used as a matrix in protein mass spectrometry.
Sinapic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
cis-Sinapic acid, also known as cis-sinapate or synapitic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. cis-Sinapic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. Within the cell, cis-sinapic acid is primarily located in the cytoplasm. Outside of the human body, cis-sinapic acid can be found in common pea and pulses. This makes cis-sinapic acid a potential biomarker for the consumption of these food products.
Cis-sinapic acid is a 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid in which the double bond has cis-configuration. It has been isolated from the shoots of alfalfa. It has a role as a plant metabolite., Application of C11H12O5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem