Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. COA of Formula: C6H14O3.
Sanders, Alyssa B.;Zangaro, Jacob T.;Webber, Nakoa K.;Calhoun, Ryan P.;Richards, Elizabeth A.;Ricci, Samuel L.;Work, Hannah M.;Yang, Daniel D.;Casey, Kaitlyn R.;Iovine, Joseph C.;Baker, Gabriela;Douglas, Taylor V.;Dutko, Sierra B.;Fasano, Thomas J.;Lofland, Sarah A.;Rajan, Ashley A.;Vasile, Mihaela A.;Carone, Benjamin R.;Nucci, Nathaniel V. research published 《 Optimization of Biocompatibility for a Hydrophilic Biological Molecule Encapsulation System》, the research content is summarized as follows. Despite considerable advances in recent years, challenges in delivery and storage of biol. drugs persist and may delay or prohibit their clin. application. Though nanoparticle-based approaches for small mol. drug encapsulation are mature, encapsulation of proteins remains problematic due to destabilization of the protein. Reverse micelles composed of decylmonoacyl glycerol (10MAG) and lauryldimethylamino-N-oxide (LDAO) in low-viscosity alkanes have been shown to preserve the structure and stability of a wide range of biol. macromols. Here, we present a first step on developing this system as a future platform for storage and delivery of biol. drugs by replacing the non-biocompatible alkane solvent with solvents currently used in small mol. delivery systems. Using a novel screening approach, we performed a comprehensive evaluation of the 10MAG/LDAO system using two preparation methods across seven biocompatible solvents with anal. of toxicity and encapsulation efficiency for each solvent. By using an inexpensive hydrophilic small mol. to test a wide range of conditions, we identify optimal solvent properties for further development. We validate the predictions from this screen with preliminary protein encapsulation tests. The insight provided lays the foundation for further development of this system toward long-term room-temperature storage of biologics or toward water-in-oil-in-water biol. delivery systems.
111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., COA of Formula: C6H14O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem