Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Related Products of 111-90-0.
Nnamani, Petra O.;Ugwu, Agatha A.;Nnadi, Ogechukwu H.;Kenechukwu, Franklin C.;Ofokansi, Kenneth C.;Attama, Anthony A.;Lehr, Claus-Michael research published 《 Formulation and evaluation of transdermal nanogel for delivery of artemether》, the research content is summarized as follows. Nanostructured lipid carrier (NLC) formulations were prepared using optimized ART concentration of 0.25 g dissolved in 5% w/v mixture of solid (Gelucire 43/01 and Phospholipon 85G) and liquid (Transcutol) lipids at 90°C. An aqueous surfactant phase at 90°C was added (dropwise) under magnetic stirring (1000 rpm) for 5 min. The pre-emulsion was speedily homogenized at 28,000 rpm for 15 min and further probe sonicated at 60% amplitude (15 min). Resultant sample was cooled at room temperature and frozen at -80°C prior to lyophilization. The freeze-dried sample was used for solid-state characterization as well as in the formulation of transdermal nanogels using three polymers (Carbopol 971P, Poloxamer 407, and Prosopis africana peel powder) to embed the ART-NLC, using ethanol as a penetration enhancer. Transdermal ART-nanogels were characterized accordingly (phys. examination, pH, drug content, rheol., spreadability, stability, particle size and morphol., skin irritation, in vitro and ex vivo skin permeation, and anal. of permeation data), P < 0.05. Overall, ART nanogels prepared from Poloxamer 407 showed the most desirable drug permeation, pH, swellability, spreadability, viscosity, and transdermal antiplasmodial properties superior to PAPP-ANG > C971P-ANG. A two-patch/wk concurrent application of the studied nanogels could ofer 100% cure of malaria as a lower-dose (50 mg ART) patient-friendly regimen devoid of the drug’s many side efects.
111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Related Products of 111-90-0
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem