Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Application In Synthesis of 122775-35-3.
Mudasani, Gopal;Paidikondala, Kalyani;Gurska, Sona;Maddirala, Shambabu Joseph;Dzubak, Petr;Das, Viswanath;Gundla, Rambabu research published 《 C-5 Aryl Substituted Azaspirooxindolinones Derivatives: Synthesis and Biological Evaluation as Potential Inhibitors of Tec Family Kinases》, the research content is summarized as follows. In this review, a structure-activity relationship study of a new series of 5′-(benzo[d][1,3]dioxol-5-yl)spiro[piperidine-4,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one linked with N-acyl and C-5 aryl-substituted scaffolds I [R = 3,4-difluorophenyl, 3,4,5-trimethoxyphenyl, benzodioxol-5-yl, etc.; R1 = H, (1-fluorocyclopropyl)carbonyl, 2-fluoro-2-methylpropanyl, biotinyl, [1-(methoxycarbonyl)cyclopropyl]carbonyl, etc.] in a panel of interleukin-2-inducible kinase (ITK) and Bruton tyrosine kinase (BTK) cancer cell lines was conducted. Four compounds I [R = benzodioxol-5-yl; R1 = (1-fluorocyclopropyl)carbonyl, 2-fluoro-2-methylpropanyl, biotinyl, [1-(methoxycarbonyl)cyclopropyl]carbonyl] showed high antiproliferative activity against ITK and BTK cell lines. Compounds I [R = benzodioxol-5-yl; R1 = (1-fluorocyclopropyl)carbonyl, 2-fluoro-2-methylpropanyl] with a C-5 benzodioxole group and gem-dialkyl group attached to carbonyl on piperidine were highly effective in ITK-high Jurkat and CEM cell lines, and compound I [R = benzodioxol-5-yl; R1 = biotinyl], a biotin analog, was identified as a good inhibitor of BTK-high RAMOS cells. Compound I [R = benzodioxol-5-yl; R1 = [1-(methoxycarbonyl)cyclopropyl]carbonyl] with cyclopropyl group attached to carbonyl on piperidine also showed good activity in ITK and BTK cell lines.
Application In Synthesis of 122775-35-3, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem