Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Safety of 2-Methoxy-N-methylethanamine.
Miyazaki, Masaki;Naito, Hiroyuki;Sugimoto, Yuuichi;Kawato, Haruko;Okayama, Tooru;Shimizu, Hironari;Miyazaki, Masaya;Kitagawa, Mayumi;Seki, Takahiko;Fukutake, Setsuko;Aonuma, Masashi;Soga, Tsunehiko research published 《 Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold》, the research content is summarized as follows. With the aim of discovering potent inhibitors of the p53-MDM2 interaction and thus obtaining a potent anticancer drug, we have pursued synthesis and optimization of dihydroimidazothiazole derivatives, which have been discovered via scaffold hopping by mimicking the mode of interaction between MDM2 and Nutlins. Upon the discovery we encountered a problem involving the chem. instability of the scaffold, i.e., susceptibility to oxidation which led to imidazothiazole. In order to solve this problem and to obtain further potent compounds, we executed medicinal research and thus furnished the optimal compounds by incorporating the Me group onto the C-6 position to avoid the oxidation, and by modifying the C-2 moiety of the addnl. proline motif, which furnished high potency. The incorporation of the pyrrolidine moiety at the C-2 position raised another hydrophobic interaction site with MDM2 protein, which was generated by the induced-fitting observed by co-crystal structure anal. These optimal mols. showed significant improvement in potency when compared with the early leads.
38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Safety of 2-Methoxy-N-methylethanamine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem