Mandrelli, Francesca; Blond, Aurelie; James, Thomas; Kim, Hyejin; List, Benjamin published an article in 2019, the title of the article was Deracemizing α-Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis-Silyl Ketene Acetals with Water or Methanol.Electric Literature of 81616-80-0 And the article contains the following content:
We report a highly enantioselective catalytic protonation of bis-silyl ketene acetals. Our method delivers α-branched carboxylic acids, including nonsteroidal anti-inflammatory arylpropionic acids such as Ibuprofen, in high enantiomeric purity and high yields. The process can be incorporated in an overall deracemization of α-branched carboxylic acids, involving a double deprotonation and silylation followed by the catalytic asym. protonation. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Electric Literature of 81616-80-0
The Article related to alpha branched carboxylic acid catalytic asym protonation deracemization, enantioselective catalytic protonation bissilyl ketene acetal, brønsted acids, bis-silyl ketene acetals, deracemization, deuteration, disulfonimide, protonation and other aspects.Electric Literature of 81616-80-0
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