On March 6, 2020, Ling, Fei; Song, Dingguo; Chen, Linlin; Liu, Tao; Yu, Mengyao; Ma, Yan; Xiao, Lian; Xu, Min; Zhong, Weihui published an article.SDS of cas: 157869-15-3 The title of the article was Syntheses of N-Alkyl 2-Arylindoles from Saturated Ketones and 2-Arylethynylanilines via Cu-Catalyzed Sequential Dehydrogenation/aza-Michael Addition/Annulation Cascade. And the article contained the following:
A Cu-catalyzed and 4-OH-TEMPO-mediated sequential dehydrogenation/aza-Michael addition/annulation cascade reaction for the construction of N-alkyl 2-arylindoles I (R = H, 2-F, 3-OMe, 4-Cl, etc.; R1 = H, F, Cl, OMe, C(O)OCH3; R2 = H; R3 = H, Cl; R2R3 = -CH=CHCH=CH-; R4 = Ph, Me, pyridin-3-yl, thiophen-2-yl, etc.) and from facilely available saturated ketones R4C(O)CH2CH3 and 2-arylethynylanilines 2-RC6H4CC-4-R1-5-R2-6-R3C6HNH2 was described. This reaction shows high regioselectivity and tolerates a variety of functional groups. Moreover, 3-alkyl-substituted indoles II (R5 = Bu, tert-Bu, pentyl, propyl) can also be obtained when using 2-alkylethynylanilines 2-R5CCC6H4NH2 as starting materials. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).SDS of cas: 157869-15-3
The Article related to alkyl arylindole preparation regioselective, arylethynylaniline preparation ketone dehydrogenation michael cyclization tandem copper catalyst, alkylethynylaniline preparation ketone dehydrogenation michael cyclization tandem copper catalyst and other aspects.SDS of cas: 157869-15-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem