On May 24, 2021, Ftouh, Soumia; Bourgeade-Delmas, Sandra; Belkadi, Mohamed; Deraeve, Celine; Hemmert, Catherine; Valentin, Alexis; Gornitzka, Heinz published an article.COA of Formula: C13H11BrS The title of the article was Synthesis, Characterization, and Antileishmanial Activity of Neutral Gold(I) Complexes with N-heterocyclic Carbene Ligands Bearing Sulfur-Containing Side Arms. And the article contained the following:
With an estimated annual incidence of one million cases, leishmaniasis is one of the top five vector-borne diseases. Currently available medical treatments involve side effects, including toxicity, nonspecific targeting, and resistance development. Thus, new antileishmanial chem. entities are of the utmost importance to fight against this disease. The authors showed in previous studies that Au(I) complexes bearing N-heterocyclic carbene (NHC) ligands with N- or S-containing side arms have interesting biol. activities in the field of cancer, malaria and leishmaniasis. The present study evaluates the in vitro antileishmanial effects on L. infantum axenic amastigotes and their cytotoxicity for the human THP1 cell line of a new family of six new imidazolium salts and their corresponding neutral (NHC)AuICl complexes. All new compounds were characterized by classical anal. methods, and five Au complexes were analyzed by x-ray structure determinations One proligand has moderate activity (IC50 = 8.24μM) while four of the six Au complexes have IC50 values in the low or sub μM range (0.15-1.3μM), including three with selectivity index (SI) values between 46 and 108. These results suggest remarkable leishmanicidal activity in vitro for three new neutral (NHC)Au(I)Cl complexes, making them candidates for further in vivo studies, which are under study. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).COA of Formula: C13H11BrS
The Article related to gold arylimidazolylidene complex sulfur side arm preparation antileishmanial activity, crystal structure gold arylimidazolylidene complex sulfur containing side arm, mol structure gold arylimidazolylidene complex sulfur containing side arm, arylimidazolylidene ligand preparation reaction gold chloride and other aspects.COA of Formula: C13H11BrS
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