On May 29, 1991, Dubroeucq, Marie Christine; Moutonnier, Claude; Peyronel, Jean Francois; Tabart, Michel; Truchon, Alain published a patent.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid The title of the patent was Preparation of 2-(phenylacetyl)-7,7-diphenylperhydroisoindol-4-ones and analogs as substance P antagonists. And the patent contained the following:
Title compounds [I; R = H; RR = bond; R4 = Ph, halophenyl, tolyl; R5 = C(:X)CHR1R2; R1 = (un)substituted Ph, alkyl, alkoxy, etc.; R2 = H, halo, OH, alkyl, etc.; X = O, S, NR3; R3 = H, dialkylamino, (un)substituted alkyl] were prepared Thus, 4,4-diphenyl-2-cyclohexenone was cyclocondensed with PhCH2N(CH2OBu)CH2SiMe3 to give, after debenzylation and optical resolution, (3aR, 7aR)-I (R = H, R4 = Ph) (II; R5 = H) which was condensed with 2-(Me2N)C6H4CH2CO2H to give II [R5 = COCH2C6H4(NMe2)-2]. The latter gave 80% inhibition of behavioral effects induced by substance P at 10 mg/kg s.c. I drug formulations were prepared The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid
The Article related to isoindolone acyldiphenylperhydro substance p antagonist, analgesic acyldiphenylperhydroisoindolone preparation, antiinflammatory acyldiphenylperhydroisoindolone preparation, antiallergic acyldiphenylperhydroisoindolone preparation, nervous system agent acyldiphenylperhydroisoindolone preparation and other aspects.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid
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