On March 1, 2022, Dalai, Pallaba Ganjan; Palit, Kuntal; Panda, Niranjan published an article.Synthetic Route of 93-04-9 The title of the article was Generation of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C-H Halogenation. And the article contained the following:
A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and DMSO (DMSO) for C-H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur ylide, which undergoes pyrolytic elimination of ethylene by affording halonium ions. These ions were accumulated and stabilized by DMSO through coordination by forming halogen cation pools for the halogenation reaction. This protocol was selective for electrophilic monohalogenation of arenes at room temperature; however, polyhalogenated products were formed by raising the reaction temperature Late-stage halogenation of heteroarenes and some commonly marketed drugs signifies the synthetic utility of this protocol in pharmaceutical chem. Unlike the classical methods, the in-situ generated electrophilic bromonium ion was further exploited for the direct synthesis of α-diketones from the alkenes under base-free conditions. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Synthetic Route of 93-04-9
The Article related to arene dmso coordinated halogen halogenation, haloarene preparation, alkene dmso coordinated bromide halogenation, dibromoalkane preparation, diketone preparation, enamide dmso coordinated bromide intramol cyclization, oxazole preparation and other aspects.Synthetic Route of 93-04-9
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