On August 17, 2007, Arvela, Riina K.; Pasquini, Serena; Larhed, Mats published an article.Electric Literature of 929-37-3 The title of the article was Highly Regioselective Internal Heck Arylation of Hydroxyalkyl Vinyl Ethers by Aryl Halides in Water. And the article contained the following:
Highly regioselective and fast Pd(0)-catalyzed internal α-arylation of ethylene glycol vinyl ether with aryl halides was shown to be possible in water without the need for any halide scavengers or ionic liquid additives. This presents the first case of water being utilized in the selective arylation of electron-rich olefins. Resulting α-products, e.g. I, were hydrolyzed and isolated as corresponding acetophenones, e.g. II, in good to excellent yields when using aryl bromides and with good to moderate yields in the case of aryl iodides. Microwave irradiation was shown to be beneficial in activation of aryl chlorides toward the internal Heck arylation. The scope of the protocol was further increased to include different hydroxyalkyl vinyl ethers, these all giving selectively only branched α-products. The active role of the hydroxy group in directing the regioselectivity toward internal arylation of electron-rich olefins, even in nonpolar toluene, was revealed. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Electric Literature of 929-37-3
The Article related to acetophenone preparation green chem, hydroxyalkyl vinyl ether aryl bromide iodide chloride heck arylation, regioselective internal heck arylation palladium catalysis microwave irradiation, hydroxy neighboring group effect regioselective internal heck arylation and other aspects.Electric Literature of 929-37-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem