Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Category: ethers-buliding-blocks.
Lin, Shibo;Liang, Yuru;Cheng, Jiayi;Pan, Feng;Wang, Yang research published ã?Novel diaryl-2H-azirines: Antitumor hybrids for dual-targeting tubulin and DNAã? the research content is summarized as follows. A novel class of diaryl substituted 2H-azirines I [R = H, 4-Me, 3,4,5-tri-MeO, etc., R1 = H, 4-Me, 4-EtO, etc.] were designed based on combination of pharmacophores from Combretastatin A-4 (CA-4) and aziridine-type alkylating agents, which are known tubulin polymerization inhibitor and DNA damaging agents, resp. The antitumor activities of these compounds I were evaluated in-vitro and compound I [R = 3-F-4-MeO, R1 =3,4,5-tri-MeO] showed the most potent activities against four cancer cell lines with IC50 values ranging from 0.16 to 1.40μM. Further mechanistic studies revealed that compound I [R = 3-F-4-MeO, R1 =3,4,5-tri-MeO] worked as a bifunctional agent targeting both tubulin and DNA. In the nude mice xenograft model, compound I [R = 3-F-4-MeO, R1 =3,4,5-tri-MeO] significantly inhibited the tumor growth with low toxicity, demonstrating the promising potential for further developing novel cancer therapy with a unique mechanism.
Category: ethers-buliding-blocks, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem