Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Category: ethers-buliding-blocks.
Khade, Prashant;Pathan, Amjadkhan A. research published 《 Formulation and evaluation of microemulsion gel for transdermal delivery of nifedipine》, the research content is summarized as follows. The objective of this research was to design a new microemulsion gel for transdermal delivery of Nifedipine. For its good solubilizing capacity and skin penetration capability, a microemulsion-based system was selected. Castor oil, Tween 20, and PEG 400 were screened as oil, surfactant, and cosurfactant resp. from the solubility study. From pseudo ternary phase diagrams, the concentration of oil phase, Smix, and distilled water were determined and further processed for the formulation of Nifedipine microemulsion. Nifedipine loaded microemulsion optimized by stability study and in vitro permeation study. 1 percent weight/weight Carbopol was used to develop a microemulsion gel formulation. Using Keshary Chien diffusion cells, the efficacy of several microemulsion formulations to transport Nifedipine through the rat skin was studied in vitro. The in vitro permeation data showed that microemulsion gel increased the permeation rate (0.373 mg/cm2/h) of Nifedipine compared with the control solution (0.129 mg/cm2/h). All microemulsion formulations had droplet sizes ranging from 69 to 82 nm. The studied microemulsion gels were stable toward all stability conditions. A skin irritation study suggested that Nifedipine loaded microemulsion and microemulsion gel formulation were nonirritating and did not cause erythema. Thus, microemulsion gel systems are a promising formulation for the transdermal delivery of Nifedipine.
Category: ethers-buliding-blocks, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem