《Palladium-Catalyzed Decarbonylative Heck Coupling of Aromatic Carboxylic Acids with Terminal Alkenes》 was published in Organic Letters in 2020. These research results belong to Yu, Wenqing; Liu, Long; Huang, Tianzeng; Zhou, Xiangbing; Chen, Tieqiao. Formula: C28H28O3 The article mentions the following:
A palladium-catalyzed decarbonylative alkenylation of aromatic carboxylic acids was developed. Under the reaction conditions, various benzoic acids including those bearing functional groups coupled to terminal alkenes, producing the corresponding internal alkenes in good to high yields. Cinnamic acids and bioactive benzoic acids such as 3-methylflavone-8-carboxylic acid, probenecid, adapalene, and febuxostat were also applicable to this reaction, demonstrating the potential synthetic value of this new reaction in organic synthesis. In the experiment, the researchers used many compounds, for example, 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Formula: C28H28O3)
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Formula: C28H28O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem