In 2022,Ruan, Zhuwei; Wang, Min; Yang, Chen; Zhu, Lili; Su, Zhishan; Hong, Ran published an article in JACS Au. The title of the article was 《Total Synthesis of (+)-Hinckdentine A: Harnessing Noncovalent Interactions for Organocatalytic Bromination》.Product Details of 10365-98-7 The author mentioned the following in the article:
Synthesis of hinckdentine A, a marine-sponge-derived tribrominated indole alkaloid bearing a unique indolo[1,2-c]quinazoline skeleton, was completed in 12 steps featuring the construction of the α-quaternary carbon center by asym. azo-ene cyclization. A novel organocatalyst, e.g., 1-(3,5-bis-trifluoromethyl-phenyl)-3-[2-(diphenyl-phosphinothioyl)-phenyl]-thiourea was developed to promote high-yielding tribromination, which represents a challenging process encountered in previous syntheses. D. functional theory calculations scrutinized viable substrates and deciphered the origin of the enhancement of C8 electrophilic bromination with a bifunctional organocatalyst. Moreover, the application of organocatalyst-enabled bromination on various substrates such as 1H-indazole, 1-isothiocyanato-2,4-dimethoxybenzene, (2H-1,3-benzodioxol-5-yl)methanol, etc. was demonstrated to highlight future late functionalizations of biol. intriguing targets. In the part of experimental materials, we found many familiar compounds, such as 3-Methoxyphenylboronic acid(cas: 10365-98-7Product Details of 10365-98-7)
3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Product Details of 10365-98-7
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem