In 2019,ChemistrySelect included an article by Mellado, Marco; Salas, Cristian O.; Uriarte, Eugenio; Vina, Dolores; Jara-Gutierrez, Carlos; Matos, Maria J.; Cuellar, Mauricio. Electric Literature of C8H8O2. The article was titled 《Design, Synthesis and Docking Calculations of Prenylated Chalcones as Selective Monoamine Oxidase B Inhibitors with Antioxidant Activity》. The information in the text is summarized as follows:
The synthesis of seven new prenylated chalcones I (R = Ph, 2-HOC6H4, 4-MeOC6H4, etc.) obtained from the natural compound, 4-hydroxy-3-(3-methylbut-2-en-1-yl)acetophenone, previously isolated from S. graveolens, is reported. Five of these compounds exhibited high inhibition and selectivity against MAO-B with IC50 values in the low micromolar range. In addition, the antioxidant activity of this series was measured, with three compounds showing a better activity than the reference, butylated hydroxytoluene (BHT). Compound I (R = 4-Me2NC6H4) proved to be the best compound within the studied series (IC50 MAO-B = 8.19 μM and k DPPH = 3.73). Finally, mol. docking was performed to better understand the binding properties of these derivatives Important features for MAO-B inhibitory activity observed were hydrogen-bonding interaction between Tyr435 and nearness with Tyr398 and FAD co-factor. Therefore, these mols. were good candidates for the design of a lead compound for Parkinson’s disease. In addition to this study using 2-Methoxybenzaldehyde, there are many other studies that have used 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2) was used in this study.
2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Electric Literature of C8H8O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem