In 2014,Magano, Javier; Conway, Brian G.; Farrand, Douglas; Lovdahl, Michael; Maloney, Mark T.; Pozzo, Mark J.; Teixeira, John J.; Rizzo, John; Tumelty, David published 《Scalable and cost-effective synthesis of a linker for bioconjugation with a peptide and a monoclonal antibody》.Synthesis published the findings.Application of 139115-91-6 The information in the text is summarized as follows:
An efficient, scalable, and cost-effective synthesis of a linker, that can be employed in a bioconjugation process with a peptide and a monoclonal antibody, is presented. Several routes were investigated that resulted in the identification of a short synthesis to a key acid intermediate from inexpensive and readily available starting materials. The final coupling of this acid with an aniline to afford the desired linker has been optimized to produce multi-gram quantities of material for clin. studies. The very limited purifications needed for both intermediates and final product make this route amenable to scale. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application of 139115-91-6)
tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Application of 139115-91-6
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem