《Small organic molecules with tailored structures: initiators in the transition-metal-free C-H arylation of unactivated arenes》 was published in RSC Advances in 2020. These research results belong to Liu, Zhenghui; Wang, Peng; Chen, Yu; Yan, Zhenzhong; Chen, Suqing; Chen, Wenjun; Mu, Tiancheng. Related Products of 529-28-2 The article mentions the following:
In this article, an optimized catalytically active mol., (2-(methylamino)phenyl)methanol, was designed. A broad range of aryl iodides RI (R = 2-fluorophenyl, thiophen-3-yl, pyridin-4-yl, etc.) could be converted into the corresponding arylated products RR1 (R1 = Ph, 4-methylphenyl) at 100°C over 24 h with good to excellent yields. Mechanistic experiments verified that radicals participated in this catalytic transformation and that the cleavage of the aromatic C-H bond was not the rate determining step. A K+ capture experiment by 18-crown-6 emphasized the significance of the cation species of the strong base. Fourier transform IR spectroscopy proved that the catalytic system was activated by the hydrogen bonds between small organic mols. and tBuOK. Also, a clear mechanism was proposed. This transition-metal-free method affords a promising system for efficient and inexpensive synthesis of biaryls via a user-friendly approach, as confirmed by scale-up experiments In the experiment, the researchers used many compounds, for example, 1-Iodo-2-methoxybenzene(cas: 529-28-2Related Products of 529-28-2)
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Related Products of 529-28-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem