Category: ethers-buliding-blocksIn 2019 ,《5-Norbornene-2-carboxylic acid: Another catalytic mediator for Catellani-type reactions》 was published in Tetrahedron. The article was written by Liu, Ze-Shui; Qian, Guangyin; Gao, Qianwen; Wang, Peng; Cheng, Hong-Gang; Hua, Yu; Zhou, Qianghui. The article contains the following contents:
The discovery of inexpensive 5-norbornene-2-carboxylic acid (N4) as a general catalytic mediator (20 mol%) to facilitate ortho C-H activation and the following C-C bond formation of aryl iodides. Firstly, a co-operative catalytic system comprising N4 and palladium/XPhos complex was developed for the novel Catellani/redox-relay Heck cascade to construct tetrahydronaphthalenes e.g., I and indanes e.g., II that contain a quaternary carbon stereogenic center. The striking feature of this work was the avoidance of stoichiometric NBE mediator that were usually required for Catellani-type reactions. Preliminary results demonstrated that N4 could acted as a general catalytic mediator to replace NBE for other Catellani-type reactions, which would undoubtedly inspire future developments in the field of cooperative catalysis. Finally, control experiments indicated that the carboxylic acid moiety of N4 played an essential role in its ability to serve as a superior mediator. The experimental process involved the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Category: ethers-buliding-blocks)
1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem