Liu, Chen-Fei; Wang, Hongyu; Martin, Robert T.; Zhao, Haonan; Gutierrez, Osvaldo; Koh, Ming Joo published their research in Nature Catalysis in 2021. The article was titled 《Olefin functionalization/isomerization enables stereoselective alkene synthesis》.Quality Control of 2-(Benzyloxy)acetaldehyde The article contains the following contents:
The catalytic amounts of a non-precious N-heterocyclic carbene-Ni(I) complex in conjunction with a sterically bulky base promote site- and trans-selective union of monosubstituted olefins CH2=CHC(R1)R2 (R1 = Ph, naphthalen-1-yl, furan-2-yl, etc.; R2 = H, Me, Ph; R1R2 = 1-[(tert-butoxy)(oxo)methane]piperidin-4-yl, 1-[(tert-butoxy)(oxo)methane]azetidin-3-yl) with a wide array of electrophilic reagents R3OTf (R3 = Ph, 1-benzyl-1H-indol-5-yl, 4-methoxyphenyl, etc.) and bis(pinacolato)diboron to deliver tri- and tetrasubstituted alkenes E/Z-R3C(CH3)=CR1R2 in up to 92% yield and >98% regio- and stereoselectivity were demonstrated. The protocol is amenable to the preparation of carbon- and heteroatom-substituted C=C bonds, providing distinct advantages over existing transformations. Utility is highlighted through concise stereoselective synthesis of biol. active compounds In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Quality Control of 2-(Benzyloxy)acetaldehyde) was used in this study.
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Quality Control of 2-(Benzyloxy)acetaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem