Li, Wenwei; Zhou, Honggui; He, Yequan; Zeng, Ge; Zheng, Yumeng; Hu, Yangni; Chen, Zhongyan; Ge, Jing-Yuan; Lv, Ningning; Chen, Jiuxi published an article in 2022. The article was titled 《Synthesis of Diverse γ-Lactams via Rh-Catalyzed C(sp2)-H Addition to Aliphatic Nitriles》, and you may find the article in Organic Letters.Quality Control of m-Methoxyphenol The information in the text is summarized as follows:
An unprecedented pathway to access γ-lactams I [R1 = H, 6-Me, 5-Ph, etc.; R2 = Ph, 4-MeC6H4, 3-MeOC6H4, etc.], II [R3 = H, 5-F, 5-MeO, 5-N(CH3)2; R4 = Ph, 4-MeC6H4, Bn, etc.] and III [R5 = Me, 4-MeC6H4, 3-MeOC6H4, etc.; R6 = Me, Ph, Bn, etc.] using acetonitrile analogs as coupling partners without oxidants, ligands, and Lewis acids was reported. The reaction undergoes Rh-catalyzed C(sp2)-H addition to carbon-bound nitriles with the aid of an amide traceless auxiliary followed by an annulation sequence, featuring a broad substrate scope, good functional group tolerance, and excellent chemo/stereoselectivity. Scale-up reactions and late-stage derivatizations highlighted the potential synthetic utility of this methodol. A plausible mechanism was proposed based on mechanistic investigations. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)
m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem