《Copper-catalyzed arylated etherification of 2,2-difluoroethanol and its mechanistic study》 was written by Huang, Shuaishuai; Nie, Yixue; Yang, Jingjing; Zheng, Zhanjiang; Cao, Jian; Xu, Zheng; Xu, Liwen. SDS of cas: 2398-37-0 And the article was included in Youji Huaxue in 2020. The article conveys some information:
A mild and efficient method for the preparation of difluoroethyl aryl ethers was developed by the copper-catalyzed Ullmann-type arylated etherification reaction of aryl bromides or iodides with 2,2-difluoroethanol. This reaction proceeded smoothly in the presence of CuI and 8-hydroxyquinoline/t-BuOK and has a broad substrate scope. ESI-MS anal. supported the existence of LCu(III)Ar(OR) species during this catalytic reaction. Further d. functional theory (DFT) calculations suggested a proposed mechanism of arylated etherification reaction involving oxidative addition, followed by nucleophile substitution and reductive elimination would be rational. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3-methoxybenzene(cas: 2398-37-0SDS of cas: 2398-37-0)
1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.SDS of cas: 2398-37-0
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem