In 2019,ACS Catalysis included an article by Fricke, Christoph; Dahiya, Amit; Reid, William B.; Schoenebeck, Franziska. Formula: C7H7IO. The article was titled 《Gold-Catalyzed C-H Functionalization with Aryl Germanes》. The information in the text is summarized as follows:
The development of orthogonal Csp2-Csp2 coupling regimes to the omnipresent Pd-catalysis class would enable an addnl. dimension of modularity in the construction of densely functionalized biaryl motifs. In this context, the identification of potent functional groups for selective transformations is in high demand. Although organogermanium compounds are generally believed to be of low reactivity in homogenous catalysis, this report discloses the highly efficient and orthogonal reactivity of aryl germanes with arenes under gold catalysis. The method is characterized by mildness, the employment of an air- and moisture-stable gold catalyst, and robustness. Our mechanistic studies show that aryl germanes are highly reactive with Au(I) and Au(III). Our computational data suggest that the origin of this reactivity primarily lies in the relatively low bond dissociation energy and as such low distortion energy to reach the key bond activating transition state. In addition to this study using 1-Iodo-2-methoxybenzene, there are many other studies that have used 1-Iodo-2-methoxybenzene(cas: 529-28-2Formula: C7H7IO) was used in this study.
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Formula: C7H7IO
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem