Electric Literature of C28H28O3In 2022 ,《A Cd9+Cd271+ stem/progenitor population and the SHP2 pathway contribute to neonatal-to-adult switching that regulates tendon maturation》 was published in Cell Reports. The article was written by Fan, Chunmei; Zhao, Yanyan; Chen, Yangwu; Qin, Tian; Lin, Junxin; Han, Shan; Yan, Ruojin; Lei, Tingyun; Xie, Yuanhao; Wang, Tingzhang; Gu, Shen; Ouyang, Hongwei; Shen, Weiliang; Yin, Zi; Chen, Xiao. The article contains the following contents:
Tendon maturation lays the foundation for postnatal tendon development, its proper mech. function, and regeneration, but the critical cell populations and the entangled mechanisms remain poorly understood. Here, by integrating the structural, mech., and mol. properties, we show that post-natal days 7-14 are the crucial transitional stage for mouse tendon maturation. We decode the cellular and mol. regulatory networks at the single-cell level. We find that a nerve growth factor (NGF)-secreting Cd9+Cd271+ tendon stem/progenitor cell population mainly prompts conversion from neonate to adult tendon. Through single-cell gene regulatory network anal., in vitro inhibitor identification, and in vivo tendon-specific Shp2 deletion, we find that SHP2 signaling is a regulator for tendon maturation. Our research comprehensively reveals the dynamic cell population transition during tendon maturation, implementing insights into the critical roles of the maturation-related stem cell population and SHP2 signaling pathway during tendon differentiation and regeneration. The experimental process involved the reaction of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Electric Literature of C28H28O3)
6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Electric Literature of C28H28O3
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