Category: ethers-buliding-blocksIn 2021 ,《Synthesis of Selenopyrano[2,3-c]pyrazol-4(1H)-ones and Their C-H Activation》 was published in Synlett. The article was written by Choi, In-Hui; Jalani, Hitesh B.; Jeong, Jin-Hyun. The article contains the following contents:
A multistep protocol for synthesizing selenopyrano[2,3-c]pyrazol-4(1H)-ones I [R1 = Me, Et, i-Pr, cyclopropyl, Ph; R2 = Ph, 4-MeC6H4; R3 = H] and their aryl derivatives I [R1 = Me, Et, i-Pr, cyclopropyl, Ph; R2 = Ph, 4-MeC6H4; R3 = Ph, 3,4-(MeO)2C6H3, 4-O2NC6H4, etc.] was developed for the first time by using selenopyran ring formation via an in situ-generated selenide that reacted directly with α-halo-β-ynone-bearing substituted pyrazoles to provide the corresponding selenopyrano[2,3-c]pyrazol-4(1H)-ones. Subsequent direct C-H arylation of the compounds I effected by palladium-catalyzed Heck reactions permitted the incorporation of arene substituents onto the selenopyrano[2,3-c]pyrazol-4(1H)-ones scaffolds with moderate to good yields, and might be useful for biol. screenings. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-methoxybenzene(cas: 2398-37-0Category: ethers-buliding-blocks)
1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem