《Sulfonamide Directivity Enables Ni-Catalyzed 1,2-Diarylation of Diverse Alkenyl Amines》 was published in ACS Catalysis in 2020. These research results belong to Apolinar, Omar; Tran, Van T.; Kim, Nana; Schmidt, Michael A.; Derosa, Joseph; Engle, Keary M.. HPLC of Formula: 529-28-2 The article mentions the following:
1,2-Diarylation of alkenyl sulfonamides with aryl iodides and aryl boronic esters under nickel catalysis is reported. The developed method tolerates coupling partners with disparate electronic properties and substitution patterns. Di- and trisubstituted alkenes as well as alkenes distal from the directing group are all accommodated. Control experiments are consistent with a N-Ni coordination mode of the directing group, which stands in contrast to a previous report on amide-directed 1,2-diarylation, which involves carbonyl coordination. The synthetic utility of the method arises from the dual function of the sulfonamide as both a directing group and a masked amine nucleophile. This is highlighted by various product diversifications where complex amine compounds are synthesized in a two-step sequence of N-functionalization and deprotection of the sulfonyl group. The experimental process involved the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2HPLC of Formula: 529-28-2)
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.HPLC of Formula: 529-28-2
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