In 2022,Zoukimian, Claude; Beroud, Remy; Boturyn, Didier published an article in Organic Letters. The title of the article was 《2-hydroxy-4-methoxybenzyl as a thiol-protecting group for directed-disulfide bond formation》.Synthetic Route of C8H8O3 The author mentioned the following in the article:
The chem. synthesis of disulfide-rich peptides such as toxins can be accomplished by using numerous orthogonal cysteine-protecting groups. Herein we report the use of the Hmboff/on protecting group for directed disulfide bond formation. Its combination with classical Trt, Acm, and Mob groups was studied for the synthesis of NMB-1 and phlotoxin-1 toxins highlighting new orthogonal strategies for directed disulfide bond formation. The results came from multiple reactions, including the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Synthetic Route of C8H8O3)
2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Synthetic Route of C8H8O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem