《Synthesis and biological evaluation of berberine derivatives as a new class of broad-spectrum antiviral agents against Coxsackievirus B》 was published in Bioorganic Chemistry in 2020. These research results belong to Zeng, Qing-Xuan; Wang, Hui-Qiang; Wei, Wei; Guo, Ting-Ting; Yu, Lian; Wang, Yan-Xiang; Li, Yu-Huan; Song, Dan-Qing. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The article mentions the following:
A series of novel berberine (BBR) analogs were prepared and tested for their antiviral potencies against six different genotype Coxsackievirus B (CVB1-6) strains, taking BBR core for structural modification. Structure-activity relationship (SAR) research revealed that introduction of a primary amine through a linker at position 3 might be beneficial for both antiviral activity and safety. Compound 14c displayed most promising inhibitory potency with IC50 values of 3.08-9.94μM against tested CVBs 2-6 strains and satisfactory SI value of 34.3 on CVB3, better than that of BBR. Also, 14c could inhibit CVB3 replication through down-regulating the expression of VP1 protein and VP1 RNA. The mechanism revealed that 14c could suppress host components JNK-MAPK, ERK-MAPK and p38-MAPK activation. Therefore, BBR derivatives were considered to be a new class of anti-CVB agents with an advantage of broad-spectrum anti-CVB potency. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)
tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem