You, Guirong; Chang, Zhi-Xin; Yan, Jizhong; Xia, Chengcai; Li, Fu-Rong; Li, Hong-Shuang published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Rhodium-catalyzed sequential intermolecular hydroacylation and deconjugative isomerization toward diversified diketones》.Name: 2-Hydroxy-4-methoxybenzaldehyde The article contains the following contents:
A rhodium-catalyzed tandem intermol. hydroacylation of terminal alkyne-substituted secondary alcs. RCH(OH)(CH2)nCCH (R = Ph, thiophen-3-yl, Pr, etc.; n = 0, 1, 2) (I) with chelating aldehydes 2-OH-R1C6H3CHO (R1 = 3-CF3, 4-Cl, 5-NO2, etc.) and deconjugative isomerization of the resulting α,β-unsaturated ketones for the preparation of synthetically valuable 1,4-diketones 2-OH-R1C6H3C(O)CH2CH2C(O)R (II) is developed. Of note, the completely atom-economical protocol can be extended to the alkynyl alcs. (I) with appropriate carbon chain length, from which 1,5-diketone/1,6-diketone 2-OH-C6H4C(O)(CH2)nC(O)C6H5 (n = 3, 4) were obtained involving the short-range deconjugative isomerization. Given its robustness, broad substrate scope, and excellent regioselectivity, this approach provides a promising platform for the synthesis of diverse diketones (II). The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Name: 2-Hydroxy-4-methoxybenzaldehyde)
2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Name: 2-Hydroxy-4-methoxybenzaldehyde
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